QResearch

QResearch Project Summaries

Approved Research Programs and Projects

Evaluation of the NHS Health Checks in England 2013-2017

Adults in England are entitled to a free NHS Health Check to find out whether they are at risk of heart disease, stroke, diabetes, kidney disease, or dementia, and they are offered support to reduce the chance of developing these conditions. Everyone.. [read more]

Antidepressant Decision Aid Tools and Risk Assessment

Depression is very common affecting up to 11% of the population. One of the treatments for depression is antidepressant medication. There are many different types of antidepressants and most of them are effective. Some antidepressants have more adver.. [read more]

Prostate specific antigen (PSA) testing in the UK population and its implications

Screening tests can be used to find cancers at an early stage before symptoms appear. For prostate cancer, a blood test called PSA can be used. A good screening test should find prostate cancers earlier, before they have spread to other parts of the .. [read more]

Hormone Replacement Therapy and Risk of Breast Cancer

This study will quantify the risks of breast cancer associated with different types of hormone replacement therapy (HRT) in order to provide women and their clinicians with the best information to inform treatment decisions. In November 2015, NICE .. [read more]

Antidepressants study in adults less than 65 years

Antidepressants are one of the most commonly prescribed medications worldwide, and their use is increasing. There is some evidence that certain illnesses and harmful events could be caused by antidepressants, so the study was carried out to see wheth.. [read more]

Risk of thrombosis in women prescribed Hormone Replacement Therapy

Hormone replacement therapy (HRT) is used to relieve adverse symptoms and reduce risk of chronic conditions in women going through menopause. There are different therapy types, which depend on the symptoms experienced by an individual.  Some women re.. [read more]

Anticholinergic drugs and the risk of dementia: a nested case control study.

Dementia is a common condition in older people, with serious consequences for affected individuals and their families and carers. Several factors can increase the risk of developing dementia such as older age, obesity, smoking, alcohol and having oth.. [read more]

Validating a postpartum venous thromboembolism risk prediction model using QResearch

Having a blood clot develop in a vein, known as a venous thromboembolism (VTE), can happen more often in young women after giving birth. Although it is rare, it is very serious and is a leading cause of maternal deaths in high-income countries, so pr.. [read more]

Establishing the validity of a case-finding tool to identify patients with familial hypercholesterolaemia

Familial Hypercholesterolaemia (FH) is a common inherited cause of raised cholesterol, affecting up to 320,000 people in the UK. However, over 80% of people with the condition are still not identified, leading to many avoidable heart attacks and earl.. [read more]

Comparison of Co-morbidity and Investigations For People with Diabetes in Bermuda and the UK.

Our objectives were to: Compare the prevalence of six major morbidities in the general population in Bermuda with the UK. This included diabetes, coronary heart disease, stroke, hypertension, heart failure and kidney failure. Characterise the pop.. [read more]

​Combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and the CPRD databases

Combined oral contraceptives (commonly known as “the pill”) are used by millions of women around the world to prevent pregnancy. As with all medicines, they have side-effects many of which are mild. However one side effect can be an increased risk of.. [read more]

Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings vs warfarin

Anticoagulants (also known as ‘blood thinning’ agents) are used to treat blood clots & also to help prevent people with irregular heartbeats from having a stroke. A stroke can be very serious as it can lead to loss of use of arms or legs, for example.. [read more]

NHS Health Checks Study 2009-2013

In England the NHS Health Check started in 2009 and is the first programme internationally aiming to improve cardiovascular disease (CVD) risk factors in an entire national adult population through behaviour change and treatment informed by CVD risk .. [read more]

Diabetes treatments and risk of cancer: a series of nested case-control studies

Type 2 diabetes is a condition which is becoming more common as the population ages and obesity levels increase. Diabetes can lead to heart disease, kidney disease and also an increased risk of some cancers. It is not known whether the increased risk.. [read more]

Cardiovascular and neuropsychatric risks of varenicline

Varenicline is a drug that can help smokers quit. However, there are concerns about possible serious adverse events in users of this drug. The aim of the current study was to assess whether varenicline is related to such events, both in the general s.. [read more]

Antiepileptic drugs and metastasis

Cancers often spread to distant sites in the body to form secondary tumours. This process is called metastasis. In order to metastasise, cancer cells need to invade through surrounding tissue. Metastasis is rarely curable. If we could slow the spread.. [read more]

QFracture - risk of osteoporotic fracture

QFracture is a risk prediction algorithm which calculates an individual’s risk of osteoporotic fracture taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. Osteoporotic fracture is identified ac.. [read more]

QDiabetes Risk Assessment Tool

QDiabetes is a risk prediction algorithm which calculates an individual’s risk of type 2 diabetes taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. Type 2 diabetes is identified according to c.. [read more]

QKidney - predicting the risk of chronic kidney disease

QKidney is a risk prediction algorithm which calculates an individual’s risk of moderate or severe kidney disease taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. Moderate or severe kidney di.. [read more]

QStroke - risk of iscahemic stroke

QStroke is a risk prediction algorithm which calculates an individual’s risk of ischaemic stroke taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. Ischaemic stroke is identified according to c.. [read more]

QThrombosis - risk of thrombosis

QThrombosis is a risk prediction algorithm which calculates an individual’s risk of thrombosis taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. Ischaemic stroke is identified according to cli.. [read more]

QAdmissions, QFrailty and QMortality

QAdmissions is a risk prediction algorithm which calculates an individual’s risk of emergency admission taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. Ischaemic stroke is identified accordi.. [read more]

QStatin - risk of unintended effects from statin medication

QStatin is a risk prediction algorithm which calculates an individual’s risk of cataract, myopathy, acute renal failure and liver dysfunction taking account of their individual risk factors such as age, sex, ethnicity, clinical values and diagnoses. .. [read more]

QCancer Risk Assessment Tools

QCancer is an evolving family of risk prediction algorithm which calculates (a) an individual’s risk of having a current cancer and (b) risk of developing cancer in the next 10 years and (c) survival for patients with a diagnosis of cancer. E.. [read more]

QDiabetes​ - Risk of diabetes related complications

This project includes two aspects: 1.   To quantify the risk of each complication associated with different diabetes treatments. There are many different treatments for patients with diabetes. Clinical trials have generally shown that these treatm.. [read more]

Predicting survival outcomes for patients with a new diagnosis of cancer

Outcomes for patients with cancer in the UK tend to be worse than those for similar developed countries worldwide. The reason for this isn’t fully understood but may reflect delays in diagnosis and variations in uptake of cancer treatments. Improving.. [read more]

Validation of QPrediction scores in QResearch and CPRD

The QResearch database and the Clinical Practice Research Datalink (CPRD) databases are two large general practice databases which are used for research. The CPRD was set up in 1988 and is of similar nature and size to QResearch although it is derive.. [read more]

QRISK3 - a new cardiovascular risk score

To develop and validate updated prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for new and established cardiovascular risk factors which can continue to be continually updated... [read more]

QBleed - risk of bleeding

To develop and validate risk algorithms (QBleed) for estimating the absolute risk of upper gastrointestinal and intracranial bleed for patients with and without anticoagulation aged 21-99 years in primary care. QBleed is updated regularly to ensur.. [read more]

Antipsychotic use in children and adolescents

Antipsychotic medications can be prescribed to children and young people with certain mental health issues. Some of them are serious, such as schizophrenia. Others include aggression and disruptive behaviour, intellectual disability and autism, and.. [read more]

Improving Early Recognition of Motor Neurone Disease

The aim of this study is to identify and quantify patterns of ‘red flag’ symptoms associated with a diagnosis of Motor Neurone Disease (MND). The research will inform the evidence base for the subsequent development of tools in GP systems to improve .. [read more]

ADEPTS: Accelerated Diagnosis in neuroEndocrine and Pancreatic TumourS

Pancreatic cancer is the 11th most common cancer in the UK. Diagnoses are often made late when the cancer is advanced. Less than 20% of patients are suitable for surgery and 84% of patients are likely to have died within a year of diagnosis giving .. [read more]

Epidemiology of Sepsis in adults in Primary Care: an exploratory study using QResearch

Blood poisoning or septicaemia is a serious infection with a high mortality. Spotting this illness early improves the outlook for patients. Most research has been done on patients once they arrive in hospital but it is important to help GPs recognis.. [read more]