Research Programs and Projects

Research Programs and Projects
Dynamic evaluation and updating of Covid-19 risk prediction models over time: Methods and pipeline (Completed) Since the first cases of COVID-19 were confirmed in the UK in early 2020, the pandemic has impacted all of our daily lives. It became clear that some people were at greater risk of hospitalisation or death if they became infected. Researchers develop ...
CoMPuTE: Complex Multimorbidity Phenotypes, Trends, and Endpoints (Completed) Multimorbidity (having multiple diseases at one time) is a growing problem in health and social care. Both research and actual recent events have shown that those suffering from multimorbidity have greater health and care needs and worse health ou ...
DELTA - integrated Diagnostic solution for early detection of Oesophageal cAncer (Completed) Oesophageal cancer is the sixth most common cause for cancer related deaths worldwide. Compared to the rest of the European countries, UK has some of the worst outcomes mainly due to late diagnosis. The main risk factor for oesophageal cancer is ch ...
Examining the effects of obesity on the severity of COVID-19 symptoms (Completed) Infection with the coronavirus, called SARS-CoV-2, does not affect everyone equally, with some prone to get more severe illness, called COVID-19, than others. Studies so far have shown that being overweight is associated with more severe disease, but ...
COVID-19, smoking and respiratory conditions: a prospective QResearch-Case Mix Programme study (Completed) We aim to assess whether smoking reduces the risk of severe COVID-19 and whether the risk of severe COVID-19 is also reduced in people who use nicotine in the form of electronic cigarettes or nicotine replacement therapy (NRT), but do not currently s ...
Development and evaluation of a tool for predicting risk of short-term adverse outcomes due to COVID-19 in the general UK population (Completed) Introduction The first UK cases of the novel coronavirus infection that causes COVID-19 were confirmed on 24th January 2020 and the first UK death on 28th Feb 2020. Since then the virus has spread rapidly. There are currently no vaccines or treatmen ...
Seasonal trends in antidepressant prescribing and mental health diagnoses in adolescents and young adults (Completed) The antidepressant drugs prescribed to adolescents for depression and anxiety are selective serotonin reuptake inhibitors, or SSRIs. Since 2005, SSRI prescribing has been increasing in adolescents in the UK. This increase may be because more young ...
QResearch-ICNARC Coronavirus Record Linkage Project (Completed) The majority of UK residents will likely have been infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus that causes Covid-19) by the end of the current pandemic. Large numbers of people will receive hospital treatm ...
Hormone replacement therapy and dementia risk: nested case-control studies using QResearch and CPRD (Completed) Dementia is a devastating condition with serious consequences for affected individuals, families, carers and wider society. It is commonest in older people, affecting 1 in 14 over the age of 65. In the UK, there are currently about 850,000 people l ...
Dietary or weight loss advice for hypertension in diabetes in primary care (Completed) The aim of this study was to find out the proportion of people with high blood pressure or diabetes who were receiving diet or weight loss advice from their doctor. We also wanted to investigate whether certain factors, such as age, weight, gender, s ...
Improving Early Recognition of Motor Neurone Disease (Completed) The aim of this study is to identify and quantify patterns of ‘red flag’ symptoms associated with a diagnosis of Motor Neurone Disease (MND). The research will inform the evidence base for the subsequent development of tools in GP systems to improve ...
ADEPTS: Accelerated Diagnosis in neuroEndocrine and Pancreatic TumourS (Completed) Pancreatic cancer is the 11th most common cancer in the UK. Diagnoses are often made late when the cancer is advanced. Less than 20% of patients are suitable for surgery and 84% of patients are likely to have died within a year of diagnosis giving ...
Prostate specific antigen (PSA) testing in the UK population and its implications (Completed) Screening tests can be used to find cancers at an early stage before symptoms appear. For prostate cancer, a blood test called PSA can be used. A good screening test should find prostate cancers earlier, before they have spread to other parts of the ...
Hormone Replacement Therapy and Risk of Breast Cancer (Completed) Hormone replacement therapy (HRT) can be of significant benefit to women who suffer severe symptoms during menopause. This is the stage in every woman’s life when hormone production in the ovaries slows down and her periods stop. Up to 80% of women ...
Antidepressant Decision Aid Tools and Risk Assessment (Completed) Depression is very common affecting up to 11% of the population. One of the treatments for depression is antidepressant medication. There are many different types of antidepressants and most of them are effective. Some antidepressants have more adver ...
Risk of thrombosis in women prescribed Hormone Replacement Therapy (Completed) Hormone replacement therapy (HRT) is used to relieve adverse symptoms and reduce risk of chronic conditions in women going through menopause. There are different therapy types, which depend on the symptoms experienced by an individual. Some women re ...
Comparison of Co-morbidity and Investigations For People with Diabetes in Bermuda and the UK. (Completed) Our objectives were to: Compare the prevalence of six major morbidities in the general population in Bermuda with the UK. This included diabetes, coronary heart disease, stroke, hypertension, heart failure and kidney failure. Characterise the popula ...
Evaluation of the NHS Health Checks in England 2013-2017 (Completed) Adults in England are entitled to a free NHS Health Check to find out whether they are at risk of heart disease, stroke, diabetes, kidney disease, or dementia, and they are offered support to reduce the chance of developing these conditions. Everyone ...
Establishing the validity of a case-finding tool to identify patients with familial hypercholesterolaemia (Completed) Familial Hypercholesterolaemia (FH) is a common inherited cause of raised cholesterol, affecting up to 320,000 people in the UK. However, over 80% of people with the condition are still not identified, leading to many avoidable heart attacks and earl ...
Validating a postpartum venous thromboembolism risk prediction model using QResearch (Completed) Having a blood clot develop in a vein, known as a venous thromboembolism (VTE), can happen more often in young women after giving birth. Although it is rare, it is very serious and is a leading cause of maternal deaths in high-income countries, so pr ...
Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings vs warfarin (Completed) Anticoagulants (also known as ‘blood thinning’ agents) are used to treat blood clots & also to help prevent people with irregular heartbeats from having a stroke. A stroke can be very serious as it can lead to loss of use of arms or legs, for example ...
Anticholinergic drugs and the risk of dementia: a nested case control study. (Completed) Dementia is a common condition in older people, with serious consequences for affected individuals and their families and carers. Several factors can increase the risk of developing dementia such as older age, obesity, smoking, alcohol and having oth ...
Combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and the CPRD databases (Completed) Combined oral contraceptives (commonly known as “the pill”) are used by millions of women around the world to prevent pregnancy. As with all medicines, they have side-effects many of which are mild. However one side effect can be an increased risk of ...
Antidepressants study in adults less than 65 years (Completed) Antidepressants are one of the most commonly prescribed medications worldwide, and their use is increasing. There is some evidence that certain illnesses and harmful events could be caused by antidepressants, so the study was carried out to see wheth ...
NHS Health Checks Study 2009-2013 (Completed) In England the NHS Health Check started in 2009 and is the first programme internationally aiming to improve cardiovascular disease (CVD) risk factors in an entire national adult population through behaviour change and treatment informed by CVD risk ...

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