Exploring the Long-term (clinical) Outcomes following a PrEgnancy affected by Gestational Diabetes Mellitus

Gestational diabetes (GDM) is a form of diabetes that affects pregnant women. It usually goes away after giving birth. Developing GDM increases the risk of problems during pregnancy and birth, and there is evidence that women who develop GDM are at much higher risk of developing conditions like type 2 diabetes later in life. However, the long term effects of developing GDM on other conditions, have not been widely investigated.
The aim of this study is to use routine healthcare records to identify what the effects are of developing GDM on health and disease risks to women. Insight into the full effects that GDM has on women will provide a boost to research efforts for the early detection, prevention and treatment of GDM.

For purposes of clinical outcomes:
Demographic data, including age, ethnicity, deprivation, smoking and alcohol intake status
Primary care diagnosis of:
Hypertension
Cardiovascular disease
Stroke/TIA
Depression and Anxiety
Dementia
Chromic Kidney Disease
NAFLD
Cancer
PCOS

Clinical measurements:
Height
Weight
BMI
HbA1C
Cholesterol (total, LDL, HDL and HDL/LDL rato)
Triacylglycerides


Drug use:
Antihypertensives
Statins
Corticosteroids
Historical oral contraceptive use

Hospital admission dates and ICD-10 codes for deliveries (maternity) outcomes (as detailled in the data specification)


Admission for the following ICD-10 codegroups:
Cardiovascular disease event (including myocardial infactrion)
Stroke/TIA (excluding haemorragic events)

Yes, death data with all causes of death from ONS

Professor Julia Hippisley-Cox - University of Oxford 

Professor Carol Coupland - University of Nottingham

Professor Susan Jebb - University of Oxford