QResearch Project Summaries

Completed Research Programs and Projects

QResearch-ICNARC Coronavirus Record Linkage Project

The majority of UK residents will likely have been infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus that causes Covid-19) by the end of the current pandemic. Large numbers of people will receive hospital treatm ...

Dietary or weight loss advice for hypertension in diabetes in primary care

The aim of this study was to find out the proportion of people with high blood pressure or diabetes who were receiving diet or weight loss advice from their doctor. We also wanted to investigate whether certain factors, such as age, weight, gender, s ...

Improving Early Recognition of Motor Neurone Disease

The aim of this study is to identify and quantify patterns of ‘red flag’ symptoms associated with a diagnosis of Motor Neurone Disease (MND). The research will inform the evidence base for the subsequent development of tools in GP systems to improve ...

Hormone Replacement Therapy and Risk of Breast Cancer

Hormone replacement therapy (HRT) can be of significant benefit to women who suffer severe symptoms during menopause. This is the stage in every woman’s life when hormone production in the ovaries slows down and her periods stop. Up to 80% of women ...

Evaluation of the NHS Health Checks in England 2013-2017

Adults in England are entitled to a free NHS Health Check to find out whether they are at risk of heart disease, stroke, diabetes, kidney disease, or dementia, and they are offered support to reduce the chance of developing these conditions. Everyone ...

Validating a postpartum venous thromboembolism risk prediction model using QResearch

Having a blood clot develop in a vein, known as a venous thromboembolism (VTE), can happen more often in young women after giving birth. Although it is rare, it is very serious and is a leading cause of maternal deaths in high-income countries, so pr ...

Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings vs warfarin

Anticoagulants (also known as ‘blood thinning’ agents) are used to treat blood clots & also to help prevent people with irregular heartbeats from having a stroke. A stroke can be very serious as it can lead to loss of use of arms or legs, for example ...

​Combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and the CPRD databases

Combined oral contraceptives (commonly known as “the pill”) are used by millions of women around the world to prevent pregnancy. As with all medicines, they have side-effects many of which are mild. However one side effect can be an increased risk of ...

Antidepressants study in adults less than 65 years

Antidepressants are one of the most commonly prescribed medications worldwide, and their use is increasing. There is some evidence that certain illnesses and harmful events could be caused by antidepressants, so the study was carried out to see wheth ...

NHS Health Checks Study 2009-2013

In England the NHS Health Check started in 2009 and is the first programme internationally aiming to improve cardiovascular disease (CVD) risk factors in an entire national adult population through behaviour change and treatment informed by CVD risk ...

Cardiovascular and neuropsychatric risks of varenicline

Varenicline is a drug that can help smokers quit. However, there are concerns about possible serious adverse events in users of this drug. The aim of the current study was to assess whether varenicline is related to such events, both in the general s ...

Antiepileptic drugs and metastasis

Cancers often spread to distant sites in the body to form secondary tumours. This process is called metastasis. In order to metastasise, cancer cells need to invade through surrounding tissue. Metastasis is rarely curable. If we could slow the spread ...