QResearch Research articles
Authors'
response to letters on QRISK3 regarding the definition of severe mental illness
and analysis of systolic blood pressure variability. Hippisley-Cox J CC,
Brindle P. BMJ 2017;357:357. doi: https://doi.org/10.1136/bmj.j2099 [available online]
Development
and validation of risk prediction equations to estimate survival in patients
with colorectal cancer: cohort study. Hippisley-Cox J, Coupland C. BMJ 2017;357
doi: 10.1136/bmj.j2497 [available online]
Development and validation of QRISK3 risk prediction algorithms to
estimate future risk of cardiovascular disease: prospective cohort study. Hippisley-Cox
J, Coupland C, Brindle P. BMJ
2017;357 doi: 10.1136/bmj.j2099 [available online]
Cardiovascular and
neuropsychiatric risks of varenicline and bupropion in smokers with chronic
obstructive pulmonary disease. Kotz D, Viechtbauer W, Simpson CR, et al. Thorax 2017 doi:
10.1136/thoraxjnl-2017-210067 [available online]
Diabetes treatments and risk of heart
failure, cardiovascular disease and all-cause mortality: cohort study in
primary care.
Hippisley-Cox J, Coupland CA. BMJ 2016;
354; i3477 [available
online]
Discontinuation and restarting in
patients on statin therapy: a cohort study using a primary care database. Vinogradova Y, Coupland CA, Brindle
P, Hippisley-Cox J. BMJ 2016;
353:i3305. [available
online]
Diabetes treatments and
risk of amputation, blindness, severe kidney failure, hyperglycaemia and
hypoglycaemia: cohort study in primary care. Hippisley-Cox J, Coupland CA. BMJ 2016;352:i1450.
[available online]
Antidepressant
use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study
using a primary care database. Coupland
CA, Hill T, Morriss R, Moore M, Arthur A, Hippisley-Cox J. BMJ 2016;352:i1350. [available online]
ORBIT
Bleeding Risk Score and QBleed. European Heart
Journal 2015; 09;29. Hippisley-Cox J. [Available online]
The NHS
Health Check in England: an evaluation of the first 4 years. Robson
J, Dostal I, Sheikh A, Eldridge S, Madurasinghe
V, Griffiths C, Coupland C, Hippisley-Cox J. BMJ Open 2016;6(1).[Available online]
Combined
oral contraceptives and venous thromboembolism. Authors' reply to Zagarella. Vinogradova
Y, Coupland C, Hippisley-Cox J. BMJ
2015;350:h3308.[Available online]
Concerns
on “Validation of a Data Collection Tool and Stroke Risk Predictor”. Hippisley-Cox J, Coupland
CA, Brindle P. International Journal of
Stroke, 2015;10(7):E82-E82 [Available online]
Antidepressant use
and risk of epilepsy and seizures in people aged 20 to 64 years: cohort
study using a primary care database. BMC Psychiatry
2015;15(1):1-13. Hill T, Coupland C,
Morriss R, Moore MV, Hippisley-Cox J[Available online]
Sodium
channel-inhibiting drugs and survival of breast, colon and prostate cancer: a
population-based study. Fairhurst C, Watt I, Martin F, et al. Scientific Reports 2015;5:16758. [Available online]
Development and validation of risk prediction equations to
estimate future risk of blindness and lower limb amputation in patients with
diabetes: cohort study. Hippisley-Cox J, Coupland CA. BMJ
2015;351:h5441. [Available online]
Development and validation of risk prediction equations to estimate future risk of heart failure in patients with diabetes: prospective cohort study. Hippisley-Cox J, Coupland CA. BMJ Open 2015;5; 9; e008503. doi:10.1136/bmjopen-2015-008503 [Available online]
Cardiovascular and neuropsychiatric risks of varenicline: a retrospective
cohort study. Kotz D, Viechtbauer W, Simpson C, et al. The Lancet Respiratory Medicine 7 September 2015 [Available online].
Use of combined oral
contraceptives and risk of venous thromboembolism: nested case-control studies
using the QResearch and CPRD databases. Vinogradova Y, Coupland C, Hippisley-Cox J.
BMJ 2015; 10.1136/bmj.h2135 [Available online]
Response to letter on statin use and risk of
cataracts: firm conclusions are still off. Journal of cardiovascular
pharmacology and therapeutics. Hippisley-Cox
J. 2015; doi 1177/1074248415591699 [Available online]
Development and validation of risk prediction algorithms to estimate future risk of common cancers in primary care: prospective cohort study. Hippisley-Cox J Coupland CA. BMJ Open 2015; doi 10.1136/bmjopen-2015-007825 [Available online]
Antidepressant
use and risk of suicide and attempted suicide/self-harm in people aged 20 to
64: cohort study using a primary care database. Coupland
CA, Hill T, Morriss R, Arthur A, Moore M, Hippisley-Cox J. BMJ 2015;350:h517 [Available online]
Exposure to sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the QResearch primary care database. Fairhurst C, Watt I, Martin M, Bland M, Brackenbury WJ. BMJ Open 2014; 4; e006604 doi: 10.1136/bmjopen-2014-006604. [Available online].
Predicting risk of upper
gastrointestinal bleed and intracranial bleeding with anticoagulants:
prospective cohort study to derive and validate the QBleed score. Hippisley-Cox J, Coupland CA.
BMJ 2014; 349; g4606.
[available online]
The performance of seven
QPrediction risk scores in an independent external sample of patients from
general practice: a validation study. Hippisley-Cox J, Coupland CA,
Brindle P. BMJ Open 2014;4(8):e005809
[available online]
Validation of QRISK2-2014 in patients with diabetes. Hippisley-Cox J, Coupland CA, Brindle P.
[available online]
Cardiovascular and
neuropsychiatric safety of varenicline and bupropion compared with nicotine
replacement therapy for smoking cessation: study protocol of a retrospective
cohort study using the QResearch® general practice database.
Kotz D, Simpson C, Viechtbauer
W, van Schayck OCP, West R,
Sheikh A. BMJ Open 2014; 4; 8; e005281 doi:10.1136/bmjopen-2014-005281. [available online]
Chickenpox
and Risk of Stroke: A Self-controlled case Series Analysis. Thomas
SL, Minassian C, Ganesan V, Langan SM, Smeeth L. Clinical Infectious Diseases.
2014; 58(1); 61-8 [available
online]
Exposure
to hormonal contraceptives and risk of venous thromboembolism: a protocol for
nested case-control studies using the QResearch and the CPRD databases. Vinogradova Y, Coupland CA,
Hippisley-Cox J. BMJ Open 2014; 4 4:e004499 doi:10.1136/bmjopen-2013-004499 [available online]
Economic evaluation of a pharmacist-led IT-based
intervention with simple feedback in reducing rates of clinically important
errors in medicines management in general practices (PINCER). A report for the
Department of Health Patient Safety Research Portfolio. Elliott RA, Putman K, Franklin
M, Verhaeghe, Annemans, Eden M, Hayre Jm Rodgers S, Cantrill J et al., 2013 [available
online]
Derivation and validation of QStroke score for predicting
risk of ischaemic stroke in primary care and comparison with other risk scores:
a prospective open cohort study. Hippisley-Cox J, Coupland C, Brindle P. British
Medical Journal 2013;346 doi:
10.1136/bmj.f2573 [available
online]
Predicting
risk of emergency admission to hospital using primary care data: derivation and
validation of QAdmissions. Hippisley-Cox J, Coupland CA. BMJ Open 2013;3:e003482 doi:10.1136/bmjopen-2013-003482. [available online]
Exposure
to bisphosphonates and risk of common non-gastrointestinal cancers: series of
nested case-control studies using two primary care databases . Vinogradova Y, Coupland C,
Hippisley-Cox J. British Journal of
Cancer; 2013; 10.1038/bjc.2013.383.[available
online]
Safety of
antidepressants in adults aged under 65: protocol for a cohort study using a
large primary care database. Coupland C, Morriss R, Arthur A, Moore M, Hill T, Hippisley-Cox J. BMC
Psychiatry 2013;13(1):135 [available online]
Exposure to bisphosphonates and risk of
gastrointestinal cancers: series of nested case-control studies with QResearch
and CPRD data.
Vinogradova Y, Coupland C, Hippisley-Cox J. British Medical Journal 2013; 346 (First Published Online 16
January):f114 [available online]
Symptoms and risk factors to identify men
with suspected cancer in primary care: derivation and validation of an
algorithm. Hippisley-Cox J, Coupland C. British Journal of General Practice
2013; Advance online Publication (12 December): e1-e10 [available online]
Symptoms and risk factors to identify women
with suspected cancer in primary care: derivation and validation of an
algorithm. Hippisley-Cox J, Coupland C. British Journal of General Practice
2013; Advance online Publication (12 December): e11-e21 [available online]
Bisphosphonates and
gastrointestinal cancers: Authors reply to Abrahamsen and colleagues. Vinogradova Y,
Coupland CA, Hippisley-Cox J. British Medical Journal 2013;346:f1518 [available online]
Validity
and completeness of the NHS number in primary and secondary care: electronic
data in England 1991-2013. Hippisley-Cox J. University of Nottingham (2013). [Available here]
QRISK2 validation by ethnic group. Hippisley-Cox J, Coupland , Robson J Brindle P.
Heart 2013;305333. [available
online]
Independent external validation of QCancer
(ovarian). Hippisley-Cox J, Coupland C. European Journal
of Cancer Care 2013;22;4;560 [available
online]
Electronic healthcare databases for
active drug safety surveillance: is there enough leverage? Coloma PM, Trifirò G, Schuemie MJ, Gini R, Herings R,
Hippisley-Cox J, Mazzaglia G, Picelli G, Corrao G, Pedersen L, van der Lei J,
Sturkenboom M, on behalf of the E. U. A. D. R. consortium. Pharmacoepidemiology
and Drug Safety 2012; 21(6):611-621 [available online]
Risk of
stroke and oral anticoagulant use in atrial fibrillation: a cross-sectional
survey. British
Journal of General Practice 2012; 62(603): pp. e710-e717(8). Holt TA, Hunter TD, Gunnarsson C, Khan N, Cload Paul, Lip GYH. [available online]
Severe mental illness and
cardiovascular risk.
Report to West London Mental Health Trust. Hippisley-Cox J. Nottingham: University of Nottingham, July
2012 (Web version)
QRisk or Framingham? Robson J,
Hippisley-Cox J, Coupland C. British
Journal of Clinical Pharmacology 2012; 74(3): 545-546 doi: 10.1111/j.1365-2125.2012.04293.x [available online]
Lifetime risks of cardiovascular disease in
the UK. Coupland C, Hippisley-Cox J, Brindle P. New England Journal of Medicine 2012;
366(17): 1641-1643
QRisk superior in diverse South Asian
groups. Robson J,
Hippisley-Cox J, Coupland C. International
Journal of Clinical Practice 2012; 66(7): 722 [available online]
Independent
external validation of QCancer (Ovarian). Hippisley-Cox
J, Coupland C. European Journal of Cancer Care. 2012; 22 (4);
559-560. [Available online]
Adding
systematic family history enquiry to cardiovascular disease risk assessment:
clinical utility in primary care. Robson
J, Hippisley-Cox J, Brindle P. Annals of Internal Medicine 2012; 157(2);
148 (letter)
Predictive effect of heartburn and
indigestion and risk of upper GI malignancy. Hippisley-Cox J, Coupland C. British Journal of General Practice 2012;
62(596): 124-126 doi: 10.3399/bjgp12X629991 [available online]
Atrial
fibrillation and rheumatoid arthritis are cardiovascular risk factors . Hippisley-Cox J, Coupland C, Robson J, Brindle P. BMJ 2012; 344 doi: 10.1136/bmj.e2259 [available
online]
Derivation and validation of updated
QFracture algorithm to predict risk of osteoporotic fracture in primary care in
the United Kingdom: prospective open cohort study. Hippisley-Cox J,
Coupland C. British Medical Journal
2012; 344: e3427 [available
online]
Identifying patients with suspected renal
tract cancer in primary care: derivation and validation of an algorithm. Hippisley-Cox J, Coupland C. British Journal of General Practice 2012;
62(597): e251-e260 [available
online]
Exposure to bisphosphonates and risk of
cancer: a protocol for nested case–control studies using the QResearch primary
care database (Protocol). Vinogradova Y,
Coupland C, Hippisley-Cox J. BMJ Open
2012; 2(1): e000548 doi:10.1136/bmjopen-2011-000548 [available online]
Validation
of QFracture compared with FRAX. Analysis prepared for NICE 2011. Hippisley-Cox
J, Coupland CA. University of Nottingham, 2011. [available online]
Use of a large general practice
syndromic surveillance system to monitor the progress of the influenza A (H1N1)
pandemic 2009 in the UK. Harcourt
S, Smith G, Elliott A, Pebody R, Charlett A, Ibbotson S, Regan M, Hippisley-Cox
J. Epidemiology and Infection 2012; 140(1): 100-105 DOI:
10.1017/S095026881100046X [available online]
Identifying
women with suspected ovarian cancer in primary care: derivation and validation
of algorithm. Hippisley-Cox J,
Coupland C. BMJ 2012; 344: d8009 doi
10.1136/bmj.d8009 [available online]
Identifying patients
with suspected pancreatic cancer in primary care: derivation and validation of
an algorithm.
Hippisley-Cox J, Coupland C. British Journal of General Practice 2012; 62
(594): e38-e45(8) doi.org/10.3399/bjgp12X616355 [available online]
Identifying
patients with suspected colorectal cancer in primary care: derivation and
validation of an algorithm. Hippisley-Cox J,
Coupland C. Accepted British Journal of
General Practice 2012; 62(594): e29-e37(9)
doi.org/10.3399/bjgp12X616346
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252538/
Predicting risk of bladder cancer in the UK. Hippisley-Cox J, Coupland C.
British Journal of General Practitioners 2012; 10.3399/bjgp12X658160
Atrial fibrillation and
rheumatoid arthritis are cardiovascular risk factors.
Hippisley-Cox J, Coupland C, Robson J, Brindle P. BMJ
2012; 344 doi: 10.1136/bmj.e2259
Predictive effect of heartburn and indigestion and
risk of upper GI malignancy. Hippisley-Cox J, Coupland C. British Journal of General Practice 2012;
62(596): 124-126 doi: 10.3399/bjgp12X629991
Cardiovascular Risk in South Asians in a religious
setting. Robson
J, Hippisley-Cox J, Coupland C.
International Journal of General Practice 2012
Family History already included in QRISK which is
used widely in the NHS in the UK. Robson J,
Hippisley-Cox J, Brindle P. Annals of
Internal Medicine 2012; Published 27.2.12: Available at: [available
online]
A study of the safety
and harms of antidepressant drugs for older people: a cohort study using a
large primary care database. Coupland C, Dhiman P, Barton G, Morriss R,
Arthur A, Sach T, Hippisley-Cox J. Health Technology Assessment 2011; 15 (28): 1-202, iii-iv http://www.hta.ac.uk/project/1689.asp
Is low-dose aspirin use associated
with a reduced risk of colorectal cancer? A QResearch primary care
database analysis. Logan RF,
Vinogradova Y, Coupland CA, Hippisley-Cox J. Gut 2011; 60 (Supplement 1):
A3 doi:10.1136/gut.2011.239301.5 [Available online]
Bayesian
modeling to unmask and predict influenza A/H1N1pdm dynamics in London. Birrell PJ,
Ketsetzis G,
Gay NJ,
Cooper BS,
Presanis AM,
Harris RJ,
Charlett A,
Zhang XS,
White PJ,
Pebody RG,
De Angelis D.
Proceedings
of the National Academy of Sciences of the U S A. 2011; 108(45):
18238-43. Epub 2011 Oct 31. [available
online]
Combining electronic healthcare
databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR
Project. Coloma PM, Schuemie MJ,
Trifiro G, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G, Giaquinto C, Carrao
G, Perdersen L, van der Lei J, Sturkenboom M, on behalf of the EU-ARD
consortium. Pharmacoepidemiology & Drug Safety 2011; 20(1):
1-11 doi 10.1002/pds.2053 [available online]
A study of the safety
and harms of antidepressant drugs for older people: a cohort study using a
large primary care database. Coupland C, Dhiman P, Barton G, Morriss R, Arthur A,
Sach T, Hippisley-Cox J. Health Technology Assessment 2011; 15 (28): 1-202, iii-iv http://www.hta.ac.uk/project/1689.asp
Antidepressant use and the risk of adverse
outcomes in older people: a population based cohort study. Coupland CA, Dhiman
P, Morriss R, Arthur A, Barton G, Hippisley-Cox J. BMJ 2011; 343: d4551 doi: 1136/bmj.d4551 [available
online]
Development and
validation of QThrombosis, a risk prediction algorithm to estimate risk of
venous thromboembolism: prospective cohort study. Hippisley-Cox J,
Coupland CA. BMJ 2011; 343: d4656 doi: 10.1136/bmj.d4656 [available
online]
Incidence, prevalence, and trends of
general practitioner-recorded diagnosis of peanut allergy in England, 2001 to
2005. Kotz D, Simpson CR, Sheikh A.
The Journal of allergy and clinical immunology 2011; 127(3): 623-30.e1 [available online]
Identifying
patients with suspected gastro-oesophageal cancer in primary care: derivation
and validation of an algorithm. Hippisley-Cox J, Coupland C. British
Journal of General Practice 2011; 61(592): e707-e714 doi: 10.3399/bjgp11x606609
[available
online]
Identifying patients
with suspected lung cancer in primary care: derivation and validation of an
algorithm. Hippisley-Cox J, Coupland CA. British Journal
of General Practice 2011; 61(592): e715-e723 doi: 10.3399/bjgp11x606627 [available
online]
Risk of pneumonia in patients taking Statins:
population-based nested case control study. Vinogradova Y, Coupland C,
Hippisley-Cox J. British Journal of General Practice 2011; 61(592): e742-e748(7)
Exposure
to Cyclooxygenase-2 Inhibitors and Risk of Cancer: Nested Case-Control Studies. Vinogradova Y, Coupland C, Hippisley-Cox
J. British Journal of Cancer 2011;
105(3): 452-459 doi: 10.1038/bjc.2011.252
Exposure
to Cyclo-oxygenase-2 Inhibitors and risk of Cancer: nested case-control
studies. Vinogradova Y,
Coupland C, Hippisley-Cox J. Journal of Epidemiology and Community Health
2011; 65 (Supplement 1): A44-A45 doi:10.1136/jech.2011.142976b.27 [available online: journal
paper and PowerPoint
Presentation]
Exposure to Statins and risk of common cancers: a series
of nested case-control studies. Vinogradova Y,
Coupland C, Hippisley-Cox J. BMC Cancer 2011; 11: 409:
doi:10.1186/1471-2407-11-409 [available
online]
Syndromic surveillance
to assess the potential public health impact of the Icelandic volcanic ash
plume across the United Kingdom, April 2010. Elliot AJ, Singh N, Loveridge P,
Harcourt S, Smith S, Pnaiser R, Kavanagh K, Robertson C, Ramsay CN, McMenamin
J, Kibble A, Murray V, Ibbotson S, Catchpole M, McCloskey B, Smith GE. Eurosurveillance,
Volume 15, Issue 23, 10 June 2010 [available
online]
Advantages of QRISK2 (2010) – the
key issues is ethnicity and extent of reallocation. Hippisley-Cox J, Coupland C, Robson J, Brindle
P. Heart 2011; 97 (6): 515 doi:10.1136/hrt.2010.221085 [available online]
QFracture – authors response. Hippisley-Cox J, Coupland C. BMJ 2011; Published 11th
January 2011 [available online]
Early spread of the 2009 influenza
A(H1N1) pandemic in the United Kingdom - use of local syndromic data,
May-August 2009. Smith S, Smith GE, Olowokure
B, Ibbotson S, Foord D, Maguire H, Pebody R, Charlett A, Hippisley-Cox J,
Elliott AJ. Eurosurveillance 2011; 16 (3): pii=19771 [available online]
Effects of severe mental illness on
survival of people with diabetes. Vinogradova
Y, Coupland C, Hippisley-Cox J, Whyte S, Penny C. British Journal of Psychiatry
March 2010; 197: 272-277 [available online]
Derivation, validation, and
evaluation of a new QRISK model to estimate lifetime risk of cardiovascular
disease: cohort study using QResearch database. Hippisley-Cox J, Coupland C, Robson J, Brindle P. BMJ
2010; 341: c6624 doi:10.1136/bmj.c6624 (published online 9 December 2010) [available online]
Exposure to statins and risk of
common cancers: a series of nested case-control studies. Vinogradova Y, Coupland C, Hippisley-Cox J.
Longitudinal and Life Course Studies 2010; 1 (3 Supplement): 254 [available online]
Antipsychotic medication and risk of
thromboembolism: nested case-control study. Parker
C, Coupland C, Hippisley-Cox J. British Medical Journal 2010; 341:
doi:10.1136/bmj.c4245 [available online]
Trends in the epidemiology of
chronic obstructive pulmonary disease in England: a national study of 51 804
patients. Simpson CR, Hippisley-Cox J,
Sheikh A. British Journal of General Practice 2010; 60: e277-e284 [available online]
Value of syndromic surveillance in
monitoring a focal waterborne outbreak due to an unusual Cryptosporidium
genotype in Northamptonshire, United Kingdom, June – July 2008. Smith S, Elliot AJ, Mallaghan C, Modha D,
Hippisley-Cox J, Large S, Regan M, Smith GE. Eurosurveillance
2010;15(33):pii=19643 [available online]
Predicting risk of Chronic Kidney
Disease in men and women in England and Wales: prospective derivation and
external validation of the QKidneyScores. Hippisley-Cox J, Coupland CA. BMC Family Practice
2010; 11(1): 49 doi:10.1186/1471-2296-11-49 [available online]
Unintended effects of statins in men
and women in England and Wales: population based cohort study using the
QResearch database. Hippisley-Cox
J, Coupland C. BMJ 2010; 340: c2197 (online first) [available online]
Individualising the risks of statins
in men and women in England and Wales: population-based cohort study. Hippisley-Cox J, Coupland C. Heart 2010; 96:
939-947 [available online]
Trends in the epidemiology of
smoking in the UK general practice.
Simpson CR, Hippisley-Cox J, Sheikh A. British Journal of General
Practice 2010; 60: e121-e127 [available online]
Diagnostic precision of Primary Care
electronic database for study of gastrointestinal bleeding and its ability to
detect the influence of aspirin. Leighton
M, Vinogradova Y, Shonde A, Atherton JC, Logan RF, Avery A, Kendrick D,
Hippisley-Cox J, Hawkey CJ. Gastroenterology 2009; 136, (Issue 5,
Supplement 1), A-612 (Abstract T1973) [available online]
Increased Aspirin Use and Upper Gastrointestinal Bleeding
Rates in Socially Deprived Patients. Vinogradova
Y, Leighton M, Avery A, Logan RF, Kendrick D, Atherton JC, Shonde A,
Hippisley-Cox J, Hawkey CJ. Gastroenterology 2009; 136 (5,
Supplement 1): A-69 (Abstract 408) [available online]
Data mining on electronic health
record databases for signal detection in pharmacovigilance: which events to
monitor? Trifirò G, Pariente A, Coloma
PM, Kors JA, Polimeni G, Miremont-Salamé G, Catania MA, Salvo F, David A, Moore
N, Caputi AP, Sturkenboom M, Molokhia M, Hippisley-Cox J, DiazC, van der
Lei J, Fourrier-Reglat A on behalf of the EU-ADR group. Pharmacoepidemiology
& Drug Safety 2009; 18 (12): 1176-1184 [available online]
A semantic approach for the
homogenous identification of events in eight patient databases: a contribution
to the European ALERT Project. Avillach
P, Mougin Fa, Jouber Mb, Thiessard F, Pariente A, Dufour J, Trifirò
G, Polimeni G, Catania GA, Carlo Giaquintoe, Mazzaglia G, Baio
G, Herings R, Gini R, Hippisley-Cox J, Molokhia M, Pedersen L, Fourrier-Réglat
A, Sturkenboom M, Fieschi M. Studies in Health Technology and
Informatics 2009; 150: 190-194
Predicting risk of osteoporotic
fracture in men and women in England and Wales: prospective derivation and
validation of QFractureScores.
Hippisley-Cox J, Coupland C. British Medical Journal 2009:
339: b4229 doi: 10.1136/bmj.b422 [available online]
Predicting the risk of type 2
diabetes in England and Wales: prospective derivation and validation of the
QDScore. Hippisley-Cox J, Coupland
C,Robson J, Sheikh A, Brindle P. British Medical Journal 2009; 338: b880
doi: 10.1136/bmj.b880 [available online]
Co-morbidity, healthcare utilisation
and process of care measures in patients with congenital heart disease in the
UK: cross-sectional, population-based study with case–control analysis. Billet J, Cowie M, Gatzoulis MA, Voner Muhl IF, A
Majeed. Heart 2008; 94: 1194-1199 doi:10.1136/hrt.2007.122671 [available online]
Identification of new risk factors
for pneumonia: population based case control study. Vinogradova Y, Hippisley-Cox J, Coupland C. british
Journal of General Practice 2009; 59 (567): e329-e338 doi:10.3399/bjgp09x472629 [available online]
Health Inequalities in Primary Care:
Effect of Spearhead Primary care Trusts 2002-2009. Hippisley-Cox J. Report to the National Audit
Office. Nottingham: University of Nottingham, October 2009
Transmitted Infections in General
Practice: Analysis using QRESEARCH database 2002-2006. Joint Collaboration of the Health Protection Agency and
QRESEARCH, 2009
Trends in consultation rates in
General Practice 1995/1996 to 2008/2009: Analysis of the QResearch®
database. Final Report to the NHS
Information Centre and Department of Health. Hippisley-Cox J, Vinogradova Y.
Published by The NHS Information Centre for Health and Social Care, part of the
Government Statistical Service. September 2009. ISBN 978-1-84636-328-3
Predicting cardiovascular risk in
England and Wales: prospective derivation and validation of QRISK2. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J,
Minhas R, Sheikh A, Brindle P. British Medical Journal 2008; 336;
1475-1482. [available online]
Trends in the epidemiology and
prescribing for eczema in England. Simpson
C, Newton J, Hippisley-Cox J, Sheikh A. Journal of the Royal Society of
Medicine 2009; 102; 108-117. [available online]
Incidence of oronasal haemorrhage in
infancy presenting to general practice in the UK. McIntosh N, Chalmers J. British Journal British
General Practice 2008; 58( 557):877-879 [available online]
Trends in the epidemiology and
prescribing of mediciation for allergic rhinitis in England. Ghouri N, Hippisley-Cox J, Newton J, Sheikh A. Journal of
the Royal Society of Medicine 2008; 101; 466-472. [available online]
Incidence and prevalence of multiple
allergic disorders recorded in a national primary care database. Simpson C, Newton J, Hippisley-Cox J, Sheikh A. Journal of
the Royal Society of Medicine 2008;101; 558-563. [available online]
Trends in national incidence,
lifetime prevalence and adrenaline prescribing for anaphylaxis in England. Simpson C, Hippisley-Cox J, Sheikh A. Journal of
the Royal Society of Medicine 2008;101; 139-143. [available online]
Identifying undiagnosed
diabetes: cross-sectional survey of 3.6 million patients’ electronic
records. Holt T, Stables D, O’Hanlon S,
Hippisley-Cox J, Majeed A. British Journal of General Practice
2008;58;192-196. [available online]
The performance of the QRISK
cardiovascular risk prediction algorithm in an external UK sample of patients
from General Practice: a validation study. Hippisley-Cox J, Coupland CA, Vinogradova Y, Robson J,
Brindle P. Heart 2008; 94: 34-39. [available online]
Uptake of pneumococcal
polysaccharide vaccine in at-risk populations in England and Wales, 1999-2005. Pebody R, Hippisley-Cox J, Pringle M, Painter M,
Charlett A, Smith GE. Epidemiology & Infection 2008; 136:
360-369 doi:10.1017/S0950268807008436 [available online]
Trends in national incidence,
lifetime prevalence and adrenaline prescribing for anaphylaxis in England. Sheikh A, Hippisley-Cox J, Newton J, Fenty J.Journal
of the Royal Society of Medicine 2008; 101: 139-143 [available online]
Clinical Care and Delivery Quality
of diabetes care in patients with schizophrenia and bipolar disorder:
cross-sectional study. Whyte
S, Penny C, Phelan M, Hippisley-Cox J, Majeed A.
Electronic Health Indicator Data
(eHID). Fleming D, Elliott C, Pringle M,
Anderson J, Hebbrecht G, Nardi R, et al. Report to the European
Commission. Birmingham: Royal College of General Practitioners, 2008
Sexual Health in the South East: A
collaborative report by the Health Protection Agency South East and the South
East Public Health Observatory.
2008
Primary
Care Surveillance in the UK: Action, Outcomes, Benefits. Cooper DL, Smith GE, Elliott D,
Harcourt S, Loveridge P, Smith S, Ibbotson S, George R, Hippisley-Cox
J. Oral presentation. Advances in Disease
Surveillance 2007; 2: 100. [available online]
Quality of diabetes care in patients
with severe mental illness: cross-sectional study. Whyte S, Penny C, Phelan M, Hippisley-Cox J, Majeed A.
Diabetic Medicine 2007; 22: 1442-1448. [available online]
Measuring performance and missing
the point? Heath I, Hippisley-Cox J Smeeth L.
British Medical Journal 2007; 335;1075-1076 doi:10.1136/bmj.39377.387373.AD [available online]
Risk of malignancy in patients with
schizophrenia or bipolar disorder: nested case control study. Hippisley-Cox J, Vinogradova Y, Coupland C, Parker C.
Archives of General Psychiatry 2007; 64; 1368-1376 [available online].
Derivation and validation of QRISK,
a new cardiovascular disease risk score for the United Kingdom: prospective
open cohort study. Hippisley-Cox J, Coupland C,
Vinogradova Y, Robson J, May M, Brindle P. British Medical Journal 2007;
335:136-141 bmj.39261.471806.55 [available online]
Risk of colorectal cancer in
patients taking statins and non-steroidal anti-inflammatory medication: nested
case control study. Vinogradova Y, Hippisley-Cox
J, Coupland C, Logan R. Gastroenterology 2007; 133; 393-402. [available online]
Inequalities in uptake of influenza
vaccine by deprivation and risk group: time trends analysis. Coupland C, Harcourt SE, Vinogradova Y, Smith GE,
Joseph CA, Pringle M, Hippisley-Cox J. Vaccine 2007; 25 (42):
7363-7371 [available online]
Inequalities in uptake of influenza
vaccine by deprivation and risk group: time trends analysis. Coupland CAC, Harcourt S, Vinogradova Y, Smith G, Joseph C,
Pringle M, Hippisley-Cox J. Journal of Epidemiology & Community
Health 2007; 61 (Suppl 1): A40. [available online]
Rectal and postmenopausal bleeding:
consultation and referral of patients with and without severe mental health
problems. Parker C, Hippisley-Cox J, Coupland
C, Vinogradova Y. British Journal of General Practice 2007; 57:
371-376 [available online]
Inequalities in the identification
and treatment of hyperlipidaemia in coronary heart disease in patients with
serious mental health problems: cross-sectional study. Hippisley-Cox J, Parker C, Coupland C, Vinogradova Y. Heart
2007; 93: 1256-1262 doi:10.1136/hrt.2006.110171 [available online]
Developing a national primary care
based early warning system for Health Protection – a surveillance tool for the
future? Analysis of routinely collected data. Smith GE, Hippisley-Cox J, Harcourt SE, Heaps M, Painter M,
Porter, A, Pringle M. Journal of Public Health Medicine 2007; 29 (1) :75–82 [available online]
Primary Care Surveillance in the UK:
Actions, Outcomes, Benefits. Cooper
DL, Smith GE, Elliot D, Harcourt S, Loveridge P, Smith S, Ibbotson S, George R.
Hippisley-Cox J. Advances in Disease Surveillance 2007; 2: 100. [available online]
Quality of diabetes care in patients
with severe mental illness: cross-sectional study. Whyte S, Penny C, Phelan M, Hippisley-Cox J, Majeed
A. Diabetic Medicine 2007: 24 (12): 1442 - 1448 [available online]
A description of the 4th verison of the QRESEARCH
database. Report to the Department of Health, 2007. [available online].
An analysis of the top ten most commonly prescribed chemical
entities in QRESEARCH. Report to the Department of Health, 2007. [available online]
A report on basic prescribing rates in older people using
QRESEARCH. Report to the Department of Health, 2007.
Comorbidity of diseases in the new GMS contract for GPs:
analysis of QRESEARCH data. Hippisley-Cox
J, Pringle M. Report to the Department of Health, 2007. [available online]
Comparison of recording of procedures between QRESEARCH and
Hospital Episode Statistics. Hippisley-Cox
J, Ryan R, Pringle M. Report to the Department of Health, 2007. [available online]
Delivery and Organisation R&D
(NCCSDO): NCCSDO. Mant J, Barton
P, Ryan R, McManus R, Fletcher K, Kandiyali R, et al.
Determinants of consultation rates over time: Implications
for estimating the national volume of consultations. Fenty J, Coupland C, Hippisley-Cox J, Gravelle
H. QRESEARCH research highlights. Leeds: The Information Centre, 2007:79.
Diabetes in the UK: analysis of QRESEARCH data. Report
to the Department of Health, 2007. [available online]
Distribution of risk factors and cardiovascular risk in
QRESEARCH in 2007. Report to the Department of Health. Hippisley-Cox J. December 2007 [available online]
Evaluation of standards of care for osteoporosis and falls
in primary care. Hippisley-Cox
J, Bayly J, Potter J, Fenty J, Parker C. QRESEARCH research highlights. Leeds:
The Information Centre, 2007:97. [available online]
Obesity in the UK: analysis of QRESEARCH data. Report
to the Department of Health, 2007. [available online]
Patterns of prescribing of selective serotonin reuptake
inhibitors in children in QRESEARCH. Report to the Department of Health, 2007. [available online]
Polypharmacy in the elderly: an analysis of QRESEARCH
data. Report to the Department of Health, 2007. [available online]
Primary care epidemiology of allergic disorders: analysis
using QRESEARCH database 2001-2006. Hippisley-Cox J, Jumbu G, Fenty J, Holland R, A. P, Heaps M.
QRESEARCH research highlights. Leeds: The Information Centre, 2007:84. [available online]
Repeat prescribing in the elderly: an analysis of QRESEARCH
data. Report to the Department of Health, 2007. [available online]
Report to the National Audit Office: Quality of care for
Stroke and TIA in General Practice using the new GMS contract
indicators. [available Online
Revising
the General Medical Services Formula. Hippisley-Cox J, Coupland
C, Pringle M, Marshall A, Ford J, Report to the Information Centre, 2007
QRESEARCH data. Report to the Department of Health,
2007. [available online]
Quality and Outcomes Time Series Analysis in QRESEARCH 2001
to 2006. Hippisley-Cox J, Vinogradova Y,
Coupland C, Heaps M. QRESEARCH research highlights. Leeds: The Information
Centre, 2007:39 [available online]
The population prevalence and inter-practice variation fo
diabetes: analysis of QRESEARCH data. Report to the Department of Health, 2007.[available online]
Trends and variations in GMS indicators for coronary heart
disease: analysis of QRESEARCH data. Report to the Department of Health, 2007.[available online]
Trends and variations in GMS indicators for diabetes:
analysis of QResearch data. Report to
the Department of Health, 2007
Trends and variations in GMS indicators for hypertension:
analysis of QResearch data. Report to
the Department of Health 2007
Trends in Consultation Rates in General Practice 1995 to
2006: Analysis of the QRESEARCH database. Hippisley-Cox J, Fenty J, Heaps M. QRESEARCH research
highlights. Leeds: The Information Centre, 2007:29. [available online]
Types of clinical and administrative user in
QRESEARCH. Report to the Department of Health, 2007. [available online]
Validation of QFLU – comparison of key indicators with
the RCGP weekly returns service 2003-2006. Hippisley-Cox J, Fenty J, Fleming D,
Elliott A, Porter A. Report to the Health Protection Agency, 2007
What is the Optimum Model of Service Delivery for Transient
Ischaemic Diabetes in the UK: analysis of QRESEARCH data. Report to the
Department of Health, 2007. [available online]
Risk of malignancy in patients with
mental health problems (abstract). Vinogradova
Y, Hippisley-Cox J, Coupland C, Parker C. Family Practice 2006; 23: 1-142
Supplement
The effect of statins on mortality
in patients with ischaemic heart disease: population-based cohort study with
case control analysis. Hippisley-Cox
J, Coupland CAC. Heart 2006; 92; 752-758 [available online]
Sex inequalities in access to care
for patients with diabetes in primary care: questionnaire survey. Hippisley-Cox J, Yates J, Pringle M, Coupland CAC,
Hammersley V. British Journal of General Practice 2006; 56; 342-348 [available online]
QFLU: new influenza monitoring in UK
primary care to support pandemic influenza planning. Hippisley-Cox J, Smith S, Smith G, Porter A, Heaps M,
Holland R, Fenty J, Harcourt S, George R, Charlett A, Pebody R, Painter M. Euro
Surveillance 2006 Jun 22;11(6):E060622.4 [available online]
Determinants
of consultation rates over time: implications for estimating the national
volume of consultations. Fenty J, Coupland
C, Hippisley-Cox J, Gravelle H. Report to the Health and Social Care
Information Centre, 2006
Factors associated with variations in consultation
rates. Fenty J, Coupland C, Hippisley-Cox J. Report to the
NHS Information Centre, April 2006
Health outcomes for patients with serious mental
health problems. Hippisley-Cox J, Parker C, Vinogradova Y, Coupland C. Second report to the
Disability Rights Commission, February 2006
Primary care epidemiology of allergic
disorders: analysis using QRESEARCH database 2001-2006. Hippisley-Cox
J, Jumbu G, Fenty J, Holland R,
Porter A, Heaps M. Report to the Health and Social Care
Information Centre, 2006
Quality of care and health outcomes for
patients with serious mental health problems. Hippisley-Cox J, Parker C, Vinogradova
Y, Coupland C. Report to the Disability Rights Commission, 2006
Risk
of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or
conventional non-steroidal anti-inflammatory drugs: population based nested
case-control analysis. Hippisley-Cox
J, Coupland CA. British Medical Journal
2005; 330: 1366-1374 [available online]
Effect
of combinations of drugs on all cause mortality in patients with ischaemic
heart disease: nested case control analysis.
Hippisley-Cox J, Coupland CAC. British
Medical Journal 2005; 330: 1059-1063 [available
online]
Risk
of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 or
conventional non-steroidal anti-inflammatory drugs: population based nested
case-control analysis. Hippisley-Cox
J, Coupland CA, Logan RL. British Medical Journal 2005; 331: 1310-1316 [available
online]
Coronary
heart disease prevention and age inequalities: the first year of the National
Service Framework for CHD. Hippisley-Cox J, Pringle M, Coupland C, Cater R, Meal A.
British Journal of General Practice 2005; 514: 369-375 [available
online]
Assessing
the accuracy of a computerised decision support system for digoxin dosing in
primary care: an observational study.
Kroese, WLG, Avery AJ, Savelyich BSP, Brown NS, Schers H, Howard R,
Hippisley-Cox J, Horsfield P. Clinical Pharmacology & Therapeutics 2005;
30: 279-283 [available
online]
Smoking
cessation treatments within primary care. Prospective cohort study. Wilson A, Hippisley-Cox J, Coupland C, Coleman T, Britton J,
Barratt S. Tobacco Control 2005; 14:
242-246 [available
online]
Comparison of key practice characteristics between general
practices in England and Wales and general practices in the QRESEARCH database.
Hippisley-Cox
J, Vinogradova Y, Coupland, C, Pringle M. Report to the Information Centre,
2005 [available online]
Health Inequalities Experienced By
People With Schizophrenia And Manic Depression: Analysis Of General Practice
Data In England And Wales. Hippisley-Cox
J, Pringle M. Final
report to the Disability Rights Commission April 2005 [available online]
Quality of care for stroke and TIA in general
practice using the new GMS contract indicators. Hippisley-Cox J,
Fenty J, Langford G, Pringle M, Coupland C. Report to the National Audit
Office, November 2005
Results of the pairwise analysis for trends
in consultation rates in UK general practices the calendar years 1995 to 2004. Hippisley-Cox J,
Fenty J, Heaps M, Pringle M. Report to
the Information Centre, November 2005
Revising the GMS formula allocation formula. Hippisley-Cox J, Coupland C, Pringle M, Marshall A, Ford J. Report to the NHS Information Centre,
December 2005
Trends in consultation rates in UK general
practices the calendar years 1995 to 2004. Hippisley-Cox J, Fenty J, Heaps M,
Pringle M. Report to the Information Centre, November 2005
QRESEARCH: a new general practice
database for research. Hippisley-Cox
J, Stables D, Pringle M. Journal of Informatics in Primary Care
2004; 12; 49-50.
Identifying
patients with medication errors using the QRESEARCH database. Avery A, Hippisley-Cox J, Ryan R, Armstrong S, Morris C,
Cantrill J. Pharmacoepidemiology and Drug Safety 2004; 13 (Supplement l):
S61-62 [available online]
Association
of deprivation, ethnicity and sex with quality indicators for diabetes:
population based survey of 53,000 patients in primary care in. Hippisley-Cox J, O’Hanlon S, Coupland C. British Medical Journal 2004; 329: 1267-1269
[available
online]
Prevalence,
care and outcomes for patients with diet controlled diabetes in primary care:
cross sectional survey. Hippisley-Cox
J, Pringle M. Lancet 2004; 364: 423-442
[available
online]
Primary
and secondary prevention, and age inequalities: the effect of the first year of
the implementation of the National Service Framework for Coronary Heart Disease
in general practices in Trent: follow-up study. Hippisley-Cox J, Pringle M, Coupland C, Cater R, Meal A.
British Journal of General Practice 2004; 12: 179-184
Achievement
of new General Medical Services Indicators for Diabetes. Hippisley-Cox J, Pringle M. Report to the Department of
Health, 2004
An
analysis of prescribing of Methylphenidate Hydrochloride in QRESEARCH. Report to the Department of Health, 2004
An analysis
of prescribing of SSRIs to Children. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department
of Health, 2004
An assessment of basic data quality in the
pilot QRESEARCH database. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department
of Health, 2004
Basic
prescribing rates in older people. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department
of Health, 2004
Comparison
of the recording of procedures on QRESEARCH and HES. Hippisley-Cox J,
Pringle M, Ryan R. Report to the Statistics Division, Department of Health,
2004
Comparing
the top ten chemical entities in PACT and QRESEARCH. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department
of Health, 2004
Defining
user types in QRESEARCH. Hippisley-Cox J.
Report to the Statistics Division, Department of Health, 2004
Description
of the National Database (4th download). Hippisley-Cox J.
Report to the Department of Health, 2004
Diabetes
in the UK, 1994 to 2003. Hippisley-Cox, J. Ryan R. Report to the Department of
Health, 2004
Incidence, prevalence and care of patients
with stroke in primary care in 2004. Hippisley-Cox J, Pringle M, Ryan R. Report to the National Stroke Audit team,
2004
Incidence,
prevalence and mortality of diabetes in the UK 1994 to 2003. Hippisley-Cox J,
Ryan R. Report to the Statistics Division, Department of Health, 2004
Inter-practice
variation in the prevalence of diabetes. Hippisley-Cox J. Report to the
Department of Health, 2004
First National Stroke Audit in Primary Care - Final Report
to the National Audit Office, 2004 [available Online]
Morbidity
and mortality on the QRESEARCH database. Hippisley-Cox J, Pringle M, Ryan R. Report
to the Statistics Division, Department of Health, 2004
Polypharmacy
in the elderly.
Hippisley-Cox J, Pringle M, Ryan R.
Report to the Statistics Division, Department of Health, 2004
Prescribing
in older people by BNF Chapter. Hippisley-Cox J, Pringle M. Report to the Statistics Division, Department
of Health, 2004
Prescribing
of Methylphenidate Hydrochloride in children. Hippisley-Cox J, Pringle M, Ryan R.
Report to the Statistics Division, Department of Health, 2004
Prevalence
of conditions in the new General Medical Services. Hippisley-Cox J, Pringle M. Report to the Department of Health, 2004
Stroke: prevalence, incidence
& care in general practice 2002-2004. Hippisley-Cox
J, Pringle M, Ryan R. Final Report to the National
Stroke Audit Team, Royal College of Physicians, September 2004
The effect of age, sex, deprivation and other factors on
electrolytes in patients on ACE inhibitors or loop diuretics in primary care: a
case control study. Nwabuoku. MPH
Thesis. University of Nottingham 2004
Trends in obesity in
the UK 1994 to 2003. Hippisley-Cox J. Ryan R. Report to the
Department of Health, 2004
Understanding
QRESEARCH data structures. Hippisley-Cox J. Report to the Statistics Division,
Department of Health, 2004
Papers
Pre-QRESEARCH - illustrating the potential
The
following papers were based on general practice clinical data before QRESEARCH
was created and illustrate the potential for QRESEARCH:
General Practitioners attitudes towards provision of
services to young people aged under 16: a cross sectional survey. Bethea J, Hippisley-Cox J, Coupland CA, Pringle M. Quality
in Primary Care; 2007; 15: 11-19.
General practice characteristics associated with rates of
testing and detection of hepatitis C: cross-sectional study in Nottingham and
Derbyshire. Coupland C, Hippisley-Cox J, Smith
S, Irving W, Pringle M, Ryder S, Neal K, Cater R, Thompson B, Pugh S, Bicknell
M, Bullock D. British Journal of General Practice 2006; 56: 620-623. [available online]
Primary and secondary prevention and age inequalities - the
effect of the first year of the National Service Framework for Coronary Heart
Disease. Hippisley-Cox J, Pringle M, Cater R,
Coupland C, Meal A. British Journal of General Practice 2004; 12: 179-184
Methodology for Assessing the Usefulness of General Practice
Data for Research in One Research Network. Hippisley-Cox J, Hammersley V, Pringle M, Coupland C, Crown
N, Wright L. Health Informatics Journal 2004; 10 : 91-109.
The electronic record in primary care – regression or
progression? A cross-sectional survey. Hippisley-Cox J, Pringle M, Cater R, Wynn A, Hammersley V,
Coupland C, Hapgood R, Horsfield P, Teasdale SJ. British Medical Journal 2003;
326: 1439-1443. [available online]
A cross sectional survey of the effectiveness of lipid
lowering drugs in lowering serum cholesterol in 17 general practices: how well
do they work? Hippisley-Cox J, Cater R, Pringle M,
Coupland C. British Medical Journal, 2003; 326: 689-694 [available online]
A case-control study on the effect of hormone replacement
therapy on ischaemic heart disease. Hippisley-Cox
J, Pringle M, Crown N, Coupland C. British Journal of General Practice 2003; 53
: 191-196 [available online]
Married couples' risk of the same disease: cross sectional
study. Hippisley-Cox J, Coupland C, Pringle
M, Crown N, Hammersley V. British Medical Journal, 2002; 325: 636-638 [available online]
A comparison of research general practices and their
patients with other practices - a cross-sectional study in Trent. Hammersley V, Hippisley-Cox J, Wilson A, Pringle M. British
Journal of General Practice , 2002; 52 : 463-468 [available online]
Antidepressants as risk factor for ischaemic heart disease:
case controlled study in primary care. Hippisley-Cox
J, Pringle M, Hammersley V, Crown N, Wynn A, Coupland C. British Medical
Journal, 2001; 323: 666-669 [available online]
Sex inequalities in ischaemic heart disease in general
practice: cross sectional survey. Hippisley-Cox
J, Pringle M, Crown N, Meal A, Wynn A. British Medical Journal, 2001; 322:
832-834 [available online]
General practice workload implications for the national
service framework for coronary heart disease: cross sectional survey. Hippisley-Cox J, Pringle M. British Medical Journal, 2001;
323: 269-270 [available online]
Inequalities in access to coronary angiography and
revascularisation: the association of deprivation and location of primary care
services. Hippisley-Cox J, Pringle M. British Journal
of General Practice, 2000; 50: 449-454 [available online]
Time changes in new cases of ischaemic heart disease. Meal A, Pringle M, Hammersley V. Family Practice, 2000;
17: 394-400 [available online]
Depression as a risk factor for ischaemic heart disease in
men: population cased case-control study. Hippisley-Cox
J, Fielding K, Pringle M. British Medical Journal, 1998; 316: 1714-1749 [available online]
Are spouses of patients with hypertension at increased risk
of having hypertension? A population-based case-control study. Hippisley-Cox J, Pringle M. British Journal of General
Practice, 1998; 4: 1580-1584