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"Generating new knowledge to improve patient care"
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Publications

QRESEARCH specialises in research & analyses
using primary care electronic health data
​​

QResearch Research articles 



Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care. Hippisley-Cox J, Coupland CA.  BMJ 2016; 354; i3477 [available online]

 

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. Vinogradova Y, Coupland CA, Brindle P, Hippisley-Cox J. BMJ 2016; 353:i3305. [available online]

 

Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia and hypoglycaemia: cohort study in primary care. Hippisley-Cox J, Coupland CA. BMJ 2016;352:i1450. [available online]

 

Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using a primary care database. Coupland CA, Hill T, Morriss R, Moore M, Arthur A, Hippisley-Cox J.  BMJ 2016;352:i1350. [available online]


ORBIT Bleeding Risk Score and QBleed. European Heart Journal  2015; 09;29. Hippisley-Cox J. [Available online]​


The NHS Health Check in England: an evaluation of the first 4years. Robson J, Dostal I, Sheikh A, Eldridge S, Madurasinghe V, Griffiths C, Coupland C, Hippisley-Cox J. BMJ Open 2016;6(1).​[Available online]​


Combined oral contraceptives and venous thromboembolism. Authors' reply to Zagarella. Vinogradova Y, Coupland C, Hippisley-Cox J.  BMJ 2015;350:h3308.[Available online]  


Concerns on “Validation of a Data Collection Tool and Stroke Risk Predictor”. Hippisley-Cox J, Coupland CA, Brindle P.  International Journal of Stroke, 2015;10(7):E82-E82 [Available online]​

 

Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64 years: cohort study using a primary care database. BMC Psychiatry 2015;15(1):1-13. Hill T, Coupland C, Morriss R, Moore MV, Hippisley-Cox J[Available online​]​


Sodium channel-inhibiting drugs and survival of breast, colon and prostate cancer: a population-based study. Fairhurst C, Watt I, Martin F, et al.  Scientific Reports 2015;5:16758.​ [Available online​]


Development and validation of risk prediction equations to estimate future risk of blindness and lower limb amputation in patients with diabetes: cohort study. Hippisley-Cox J, Coupland CA. BMJ 2015;351:h5441. ​[Available online​]


Development and validation of risk prediction equations to estimate future risk of heart failure in patients with diabetes: prospective cohort study. Hippisley-Cox J, Coupland CA. BMJ Open 2015;5; 9; e008503.  doi:10.1136/bmjopen-2015-008503​ [Available online]​

 


Cardiovascular and neuropsychiatric risks of varenicline: a retrospective cohort study. Kotz D, Viechtbauer W, Simpson C, et al. The Lancet Respiratory Medicine 7 September 2015​ [Available online​].


Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. Vinogradova Y, Coupland C, Hippisley-Cox J. BMJ 2015; 10.1136/bmj.h2135​ [Available online​]

 

Response to letter on statin use and risk of cataracts: firm conclusions are still off. Journal of cardiovascular pharmacology and therapeutics. Hippisley-Cox J. 2015; doi 1177/1074248415591699  [Available online]​ 

 

Development and validation of risk prediction algorithms to estimate future risk of common cancers in primary care: prospective cohort study. Hippisley-Cox J Coupland CA. BMJ Open 2015; doi 10.1136/bmjopen-2015-007825 [Available online]


Antidepressant use and risk of suicide and attempted suicide/self-harm in people aged 20 to 64: cohort study using a primary care database. Coupland CA, Hill T, Morriss R, Arthur A, Moore M, Hippisley-Cox J. BMJ 2015;350:h517 [Available online]



Exposure to sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the QResearch primary care database. Fairhurst C, Watt I, Martin M, Bland M, Brackenbury WJ. BMJ Open 2014; 4; e006604 doi: 10.1136/bmjopen-2014-006604. [Available online]


Predicting risk of upper gastrointestinal bleed and intracranial bleeding with anticoagulants: prospective cohort study to derive and validate the QBleed score. Hippisley-Cox J, Coupland CA.  BMJ 2014; 349; g4606.

[available online]



The performance of seven QPrediction risk scores in an independent external sample of patients from general practice: a validation study. Hippisley-Cox J, Coupland CA, Brindle P. BMJ Open 2014;4(8):e005809

[available online]


Validation of QRISK2-2014 in patients with diabetes. Hippisley-Cox J, Coupland CA, Brindle P. 

[available online


Cardiovascular and neuropsychiatric safety of varenicline and bupropion compared with nicotine replacement therapy for smoking cessation: study protocol of a retrospective cohort study using the QResearch® general practice database.

Kotz D, Simpson C, Viechtbauer W,  van Schayck OCP, West R, Sheikh A. BMJ Open 2014; 4; 8; e005281 doi:10.1136/bmjopen-2014-005281. [available online​]


Chickenpox and Risk of Stroke: A Self-controlled case Series Analysis. Thomas SL, Minassian C, Ganesan V, Langan SM, Smeeth L. Clinical Infectious Diseases. 2014; 58(1); 61-8 [available online]


Exposure to hormonal contraceptives and risk of venous thromboembolism: a protocol for nested case-control studies using the QResearch and the CPRD databases. Vinogradova Y, Coupland CA, Hippisley-Cox J. BMJ Open 2014; 4 4:e004499 doi:10.1136/bmjopen-2013-004499  [available online]



Economic evaluation of a pharmacist-led IT-based intervention with simple feedback in reducing rates of clinically important errors in medicines management in general practices (PINCER). A report for the Department of Health Patient Safety Research Portfolio. Elliott RA, Putman K, Franklin M, Verhaeghe, Annemans, Eden M, Hayre Jm Rodgers S, Cantrill J et al., 2013 [available online]​

 

Derivation and validation of QStroke score for predicting risk of ischaemic stroke in primary care and comparison with other risk scores: a prospective open cohort study. Hippisley-Cox J, Coupland C, Brindle P. British Medical Journal 2013;346 doi: 10.1136/bmj.f2573 [available online]

Predicting risk of emergency admission to hospital using primary care data: derivation and validation of QAdmissions. Hippisley-Cox J, Coupland CA.  BMJ Open 2013;3:e003482 doi:10.1136/bmjopen-2013-003482. [available online]

 

Exposure to bisphosphonates and risk of common non-gastrointestinal cancers: series of nested case-control studies using two primary care databases . Vinogradova Y, Coupland C, Hippisley-Cox J.  British Journal of Cancer; 2013; 10.1038/bjc.2013.383.[available online]

 

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. Coupland C, Morriss R, Arthur A, Moore M, Hill T, Hippisley-Cox J. BMC Psychiatry 2013;13(1):135 [available online]


 

Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data. Vinogradova Y, Coupland C, Hippisley-Cox J. British Medical Journal 2013; 346 (First Published Online 16 January):f114 [available online]

 

Symptoms and risk factors to identify men with suspected cancer in primary care: derivation and validation of an algorithm.  Hippisley-Cox J, Coupland C. British Journal of General Practice 2013; Advance online Publication (12 December): e1-e10 [available online]

 

Symptoms and risk factors to identify women with suspected cancer in primary care: derivation and validation of an algorithm.  Hippisley-Cox J, Coupland C. British Journal of General Practice 2013; Advance online Publication (12 December): e11-e21 [available online]

 

Bisphosphonates and gastrointestinal cancers: Authors reply to Abrahamsen and colleagues. Vinogradova Y, Coupland CA, Hippisley-Cox J. British Medical Journal  2013;346:f1518  [available online]

 

 

Validity and completeness of the NHS number in primary and secondary care: electronic data in England 1991-2013. Hippisley-Cox J.  University of Nottingham (2013). [Available here​]

QRISK2 validation by ethnic group. Hippisley-Cox J, Coupland , Robson J Brindle P. Heart 2013;305333. [available online]

 

Independent external validation of QCancer (ovarian).  Hippisley-Cox J, Coupland C. European Journal of Cancer Care 2013;22;4;560 [available online]

 

Electronic healthcare databases for active drug safety surveillance: is there enough leverage? Coloma PM, Trifirò G, Schuemie MJ, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G, Picelli G, Corrao G, Pedersen L, van der Lei J, Sturkenboom M, on behalf of the E. U. A. D. R. consortium.  Pharmacoepidemiology and Drug Safety 2012; 21(6):611-621 [available online]

 

Risk of stroke and oral anticoagulant use in atrial fibrillation: a cross-sectional survey.   British Journal of General Practice 2012; 62(603): pp. e710-e717(8).  Holt TA, Hunter TD, Gunnarsson C, Khan N, Cload Paul, Lip GYH. [available online]

 

Severe mental illness and cardiovascular risk.  Report to West London Mental Health Trust.  Hippisley-Cox J.  Nottingham: University of Nottingham, July 2012 (Web version)

 

QRisk or Framingham? Robson J, Hippisley-Cox J, Coupland C.  British Journal of Clinical Pharmacology 2012; 74(3): 545-546 doi: 10.1111/j.1365-2125.2012.04293.x [available online]



Lifetime risks of cardiovascular disease in the UK.  Coupland C, Hippisley-Cox J, Brindle P.  New England Journal of Medicine 2012; 366(17): 1641-1643

 

QRisk superior in diverse South Asian groups.  Robson J, Hippisley-Cox J, Coupland C. International Journal of Clinical Practice 2012; 66(7): 722 [available online]

 

Independent external validation of QCancer (Ovarian). Hippisley-Cox J, Coupland C.  European Journal of Cancer Care. 2012; 22 (4); 559-560. [Available online]​


Adding systematic family history enquiry to cardiovascular disease risk assessment: clinical utility in primary care.  Robson J, Hippisley-Cox J, Brindle P.   Annals of Internal Medicine 2012; 157(2); 148  (letter)



Predictive effect of heartburn and indigestion and risk of upper GI malignancy. Hippisley-Cox J, Coupland C.  British Journal of General Practice 2012; 62(596): 124-126 doi: 10.3399/bjgp12X629991 [available online]

 

Atrial fibrillation and rheumatoid arthritis are cardiovascular risk factors . Hippisley-Cox J, Coupland C, Robson J, Brindle P.  BMJ 2012; 344 doi: 10.1136/bmj.e2259 [available online]

 

Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. Hippisley-Cox J, Coupland C.  British Medical Journal 2012; 344: e3427 [available online]

 

Identifying patients with suspected renal tract cancer in primary care: derivation and validation of an algorithm.  Hippisley-Cox J, Coupland C.   British Journal of General Practice 2012; 62(597): e251-e260 [available online]

 

Exposure to bisphosphonates and risk of cancer: a protocol for nested case–control studies using the QResearch primary care database (Protocol).  Vinogradova Y, Coupland C, Hippisley-Cox J.  BMJ Open 2012; 2(1): e000548 doi:10.1136/bmjopen-2011-000548 [available online]


Validation of QFracture compared with FRAX. Analysis prepared for NICE 2011. Hippisley-Cox J, Coupland CA. University of Nottingham, 2011. [available online​]

 

Use of a large general practice syndromic surveillance system to monitor the progress of the influenza A (H1N1) pandemic 2009 in the UK.  Harcourt S, Smith G, Elliott A, Pebody R, Charlett A, Ibbotson S, Regan M, Hippisley-Cox J. Epidemiology and Infection 2012; 140(1): 100-105 DOI: 10.1017/S095026881100046X [available online]

 

Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm.  Hippisley-Cox J, Coupland C.  BMJ 2012; 344: d8009 doi 10.1136/bmj.d8009 [available online]


 

Identifying patients with suspected pancreatic cancer in primary care: derivation and validation of an algorithm. Hippisley-Cox J, Coupland C. British Journal of General Practice 2012; 62 (594): e38-e45(8) doi.org/10.3399/bjgp12X616355 [available online]

 

Identifying patients with suspected colorectal cancer in primary care: derivation and validation of an algorithm.  Hippisley-Cox J, Coupland C.  Accepted British Journal of General Practice 2012; 62(594): e29-e37(9) doi.org/10.3399/bjgp12X616346

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252538/

 

Predicting risk of bladder cancer in the UK. Hippisley-Cox J, Coupland C. British Journal of General Practitioners 2012; 10.3399/bjgp12X658160

 

Atrial fibrillation and rheumatoid arthritis are cardiovascular risk factors. Hippisley-Cox J, Coupland C, Robson J, Brindle P.  BMJ 2012; 344 doi: 10.1136/bmj.e2259

 

Predictive effect of heartburn and indigestion and risk of upper GI malignancy.  Hippisley-Cox J, Coupland C.  British Journal of General Practice 2012; 62(596): 124-126 doi: 10.3399/bjgp12X629991  

 

Cardiovascular Risk in South Asians in a religious setting. Robson J, Hippisley-Cox J, Coupland C.    International Journal of General Practice 2012

 

Family History already included in QRISK which is used widely in the NHS in the UK.  Robson J, Hippisley-Cox J, Brindle P.   Annals of Internal Medicine 2012; Published 27.2.12: Available at:  [available online]

 

A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database. Coupland C, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, Hippisley-Cox J. Health Technology Assessment 2011; 15 (28): 1-202, iii-iv http://www.hta.ac.uk/project/1689.asp

 

Is low-dose aspirin use associated with a reduced risk of colorectal cancer?  A QResearch primary care database analysis.  Logan RF, Vinogradova Y, Coupland CA, Hippisley-Cox J.  Gut 2011; 60 (Supplement 1): A3 doi:10.1136/gut.2011.239301.5  [Available online]

 

Bayesian modeling to unmask and predict influenza A/H1N1pdm dynamics in London.  Birrell PJ, Ketsetzis G, Gay NJ, Cooper BS, Presanis AM, Harris RJ, Charlett A, Zhang XS, White PJ, Pebody RG, De Angelis D. Proceedings of the National Academy of Sciences of the U S A. 2011; 108(45): 18238-43. Epub 2011 Oct 31.  [available online]

 

Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR Project. Coloma PM, Schuemie MJ,  Trifiro G, Gini R, Herings R, Hippisley-Cox J, Mazzaglia G, Giaquinto C, Carrao G, Perdersen L, van der Lei J, Sturkenboom M, on behalf of the EU-ARD consortium.  Pharmacoepidemiology & Drug Safety 2011; 20(1): 1-11 doi 10.1002/pds.2053 [available online]

 

A study of the safety and harms of antidepressant drugs for older people: a cohort study using a large primary care database. Coupland C, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, Hippisley-Cox J. Health Technology Assessment 2011; 15 (28): 1-202, iii-iv http://www.hta.ac.uk/project/1689.asp

 

Antidepressant use and the risk of adverse outcomes in older people: a population based cohort study. Coupland CA, Dhiman P, Morriss R, Arthur A, Barton G, Hippisley-Cox J.  BMJ 2011; 343: d4551 doi: 1136/bmj.d4551 [available online] 

 

Development and validation of QThrombosis, a risk prediction algorithm to estimate risk of venous thromboembolism: prospective cohort study. Hippisley-Cox J, Coupland CA. BMJ 2011; 343: d4656 doi: 10.1136/bmj.d4656 [available online]

 

Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in England, 2001 to 2005.  Kotz D, Simpson CR, Sheikh A.  The Journal of allergy and clinical immunology 2011; 127(3): 623-30.e1 [available online]

 

Identifying patients with suspected gastro-oesophageal cancer in primary care: derivation and validation of an algorithm.   Hippisley-Cox J, Coupland C.  British Journal of General Practice 2011; 61(592): e707-e714 doi: 10.3399/bjgp11x606609 [available online]

 

Identifying patients with suspected lung cancer in primary care: derivation and validation of an algorithm.  Hippisley-Cox J, Coupland CA. British Journal of General Practice 2011; 61(592): e715-e723 doi: 10.3399/bjgp11x606627 [available online]

 

Risk of pneumonia in patients taking Statins: population-based nested case control study. Vinogradova Y, Coupland C, Hippisley-Cox J. British Journal of General Practice 2011; 61(592): e742-e748(7)

 

Exposure to Cyclooxygenase-2 Inhibitors and Risk of Cancer: Nested Case-Control Studies.  Vinogradova Y, Coupland C, Hippisley-Cox J.  British Journal of Cancer 2011; 105(3): 452-459 doi: 10.1038/bjc.2011.252

 

Exposure to Cyclo-oxygenase-2 Inhibitors and risk of Cancer: nested case-control studies.  Vinogradova Y, Coupland C, Hippisley-Cox J.  Journal of Epidemiology and Community Health 2011; 65 (Supplement 1): A44-A45 doi:10.1136/jech.2011.142976b.27 [available online: journal paper and PowerPoint Presentation]

 

Exposure to Statins and risk of common cancers: a series of nested case-control studies.  Vinogradova Y, Coupland C, Hippisley-Cox J.  BMC Cancer 2011; 11: 409: doi:10.1186/1471-2407-11-409 [available online]

 

Syndromic surveillance to assess the potential public health impact of the Icelandic volcanic ash plume across the United Kingdom, April 2010. Elliot AJ, Singh N, Loveridge P, Harcourt S, Smith S, Pnaiser R, Kavanagh K, Robertson C, Ramsay CN, McMenamin J, Kibble A, Murray V, Ibbotson S, Catchpole M, McCloskey B, Smith GE. Eurosurveillance, Volume 15, Issue 23, 10 June 2010 [available online]

 

Advantages of QRISK2 (2010) – the key issues is ethnicity and extent of reallocation.  Hippisley-Cox J, Coupland C, Robson J, Brindle P.   Heart 2011; 97 (6): 515 doi:10.1136/hrt.2010.221085 [available online]

 

QFracture – authors response.  Hippisley-Cox J, Coupland C.  BMJ 2011; Published 11th January 2011 [available online]

  

Early spread of the 2009 influenza A(H1N1) pandemic in the United Kingdom - use of local syndromic data, May-August 2009.  Smith S, Smith GE, Olowokure B, Ibbotson S, Foord D, Maguire H, Pebody R, Charlett A, Hippisley-Cox J, Elliott AJ.  Eurosurveillance 2011; 16 (3): pii=19771 [available online]

 

Effects of severe mental illness on survival of people with diabetes.  Vinogradova Y, Coupland C, Hippisley-Cox J, Whyte S, Penny C. British Journal of Psychiatry March 2010; 197: 272-277 [available online]
  

Derivation, validation, and evaluation of a new QRISK model to estimate lifetime risk of cardiovascular disease: cohort study using QResearch database.  Hippisley-Cox J, Coupland C, Robson J, Brindle P.  BMJ 2010; 341: c6624 doi:10.1136/bmj.c6624 (published online 9 December 2010) [available online]

   

Exposure to statins and risk of common cancers: a series of nested case-control studies.  Vinogradova Y, Coupland C, Hippisley-Cox J.  Longitudinal and Life Course Studies 2010; 1 (3 Supplement): 254 [available online]

 

Antipsychotic medication and risk of thromboembolism: nested case-control study. Parker C, Coupland C, Hippisley-Cox J. British Medical Journal 2010; 341: doi:10.1136/bmj.c4245 [available online]

 

Trends in the epidemiology of chronic obstructive pulmonary disease in England: a national study of 51 804 patients.  Simpson CR, Hippisley-Cox J, Sheikh A.  British Journal of General Practice 2010; 60: e277-e284 [available online]

  

Value of syndromic surveillance in monitoring a focal waterborne outbreak due to an unusual Cryptosporidium genotype in Northamptonshire, United Kingdom, June – July 2008.  Smith S, Elliot AJ, Mallaghan C, Modha D, Hippisley-Cox J, Large S, Regan M, Smith GE. Eurosurveillance 2010;15(33):pii=19643 [available online]

 

Predicting risk of Chronic Kidney Disease in men and women in England and Wales: prospective derivation and external validation of the QKidneyScores.  Hippisley-Cox J, Coupland CA.  BMC Family Practice 2010; 11(1): 49 doi:10.1186/1471-2296-11-49 [available online]

 

Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database.  Hippisley-Cox J, Coupland C.  BMJ 2010; 340: c2197 (online first) [available online]

 

Individualising the risks of statins in men and women in England and Wales: population-based cohort study.  Hippisley-Cox J, Coupland C.  Heart 2010; 96: 939-947 [available online]

 

Trends in the epidemiology of smoking in the UK general practice. Simpson CR, Hippisley-Cox J, Sheikh A.  British Journal of General Practice 2010; 60: e121-e127 [available online]

 

Diagnostic precision of Primary Care electronic database for study of gastrointestinal bleeding and its ability to detect the influence of aspirin.  Leighton M, Vinogradova Y, Shonde A, Atherton JC, Logan RF, Avery A, Kendrick D, Hippisley-Cox J, Hawkey CJ.  Gastroenterology 2009; 136, (Issue 5, Supplement 1), A-612 (Abstract T1973) [available online] 

 

Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients. Vinogradova Y, Leighton M, Avery A, Logan RF, Kendrick D, Atherton JC, Shonde A, Hippisley-Cox J, Hawkey CJ.  Gastroenterology 2009; 136 (5, Supplement 1): A-69 (Abstract 408) [available online]

 

Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor? Trifirò G, Pariente A,  Coloma PM, Kors JA, Polimeni G, Miremont-Salamé G, Catania MA, Salvo F, David A, Moore N,  Caputi AP, Sturkenboom M, Molokhia M, Hippisley-Cox J, DiazC, van der Lei J, Fourrier-Reglat A on behalf of the EU-ADR group. Pharmacoepidemiology & Drug Safety 2009; 18 (12): 1176-1184 [available online]

 

A semantic approach for the homogenous identification of events in eight patient databases: a contribution to the European ALERT Project.  Avillach P, Mougin Fa, Jouber Mb, Thiessard F, Pariente A,  Dufour J, Trifirò G, Polimeni G, Catania GA, Carlo Giaquintoe, Mazzaglia G, Baio  G, Herings R, Gini R, Hippisley-Cox J, Molokhia M, Pedersen L, Fourrier-Réglat A,  Sturkenboom M, Fieschi M. Studies in Health Technology and Informatics 2009; 150: 190-194

Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores.  Hippisley-Cox J, Coupland C.   British Medical Journal 2009: 339: b4229 doi: 10.1136/bmj.b422 [available online]

Predicting the risk of type 2 diabetes in England and Wales: prospective derivation and validation of the QDScore.  Hippisley-Cox J, Coupland C,Robson J, Sheikh A, Brindle P.  British Medical Journal 2009; 338: b880 doi: 10.1136/bmj.b880 [available online]
 

Co-morbidity, healthcare utilisation and process of care measures in patients with congenital heart disease in the UK: cross-sectional, population-based study with case–control analysis.  Billet J, Cowie M, Gatzoulis MA, Voner Muhl IF, A Majeed. Heart 2008; 94: 1194-1199 doi:10.1136/hrt.2007.122671 [available online]

 

Identification of new risk factors for pneumonia: population based case control study.  Vinogradova Y, Hippisley-Cox J, Coupland C. british Journal of General Practice 2009; 59 (567): e329-e338 doi:10.3399/bjgp09x472629 [available online]

 

Health Inequalities in Primary Care: Effect of Spearhead Primary care Trusts 2002-2009.  Hippisley-Cox J. Report to the National Audit Office.  Nottingham: University of Nottingham, October 2009​

 

Transmitted Infections in General Practice: Analysis using QRESEARCH database 2002-2006. Joint Collaboration of the Health Protection Agency and QRESEARCH, 2009

 

Trends in consultation rates in General Practice 1995/1996 to 2008/2009: Analysis of the QResearch® database.   Final Report to the NHS Information Centre and Department of Health. Hippisley-Cox J, Vinogradova Y. Published by The NHS Information Centre for Health and Social Care, part of the Government Statistical Service. September 2009.  ISBN 978-1-84636-328-3

 

Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2.  Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R, Sheikh A, Brindle P. British Medical Journal 2008; 336; 1475-1482. [available online]

 

Trends in the epidemiology and prescribing for eczema in England.  Simpson C, Newton J, Hippisley-Cox J, Sheikh A. Journal of the Royal Society of Medicine 2009; 102; 108-117. [available online]

 

Incidence of oronasal haemorrhage in infancy presenting to general practice in the UK. McIntosh N, Chalmers J.  British Journal British General Practice 2008; 58( 557):877-879 [available online]

 

Trends in the epidemiology and prescribing of mediciation for allergic rhinitis in England.  Ghouri N, Hippisley-Cox J, Newton J, Sheikh A. Journal of the Royal Society of Medicine 2008; 101; 466-472.  [available online]

  

Incidence and prevalence of multiple allergic disorders recorded in a national primary care database.  Simpson C, Newton J, Hippisley-Cox J, Sheikh A. Journal of the Royal Society of Medicine 2008;101; 558-563. [available online]

 

Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England.  Simpson C, Hippisley-Cox J, Sheikh A. Journal of the Royal Society of Medicine 2008;101; 139-143. [available online]

 

Identifying undiagnosed diabetes: cross-sectional survey of 3.6 million patients’ electronic records.  Holt T, Stables D, O’Hanlon S, Hippisley-Cox J, Majeed A. British Journal of General Practice 2008;58;192-196. [available online]

 

The performance of the QRISK cardiovascular risk prediction algorithm in an external UK sample of patients from General Practice: a validation study.  Hippisley-Cox J, Coupland CA, Vinogradova Y, Robson J, Brindle P. Heart 2008; 94: 34-39. [available online]

 

Uptake of pneumococcal polysaccharide vaccine in at-risk populations in England and Wales, 1999-2005.  Pebody R, Hippisley-Cox J, Pringle M, Painter M, Charlett A, Smith GE. Epidemiology & Infection 2008; 136: 360-369 doi:10.1017/S0950268807008436 [available online]

 

Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England.  Sheikh A, Hippisley-Cox J, Newton J, Fenty J.Journal of the Royal Society of Medicine 2008; 101: 139-143 [available online]

 

Clinical Care and Delivery Quality of diabetes care in patients with schizophrenia and bipolar disorder: cross-sectional study.  Whyte S, Penny C, Phelan M, Hippisley-Cox J, Majeed A.

 

Electronic Health Indicator Data (eHID). Fleming D, Elliott C, Pringle M, Anderson J, Hebbrecht G, Nardi R, et al.  Report to the European Commission. Birmingham: Royal College of General Practitioners, 2008

 

Sexual Health in the South East: A collaborative report by the Health Protection Agency South East and the South East Public Health Observatory. 2008

 

Primary Care Surveillance in the UK: Action, Outcomes, Benefits. Cooper DL, Smith GE, Elliott D, Harcourt S, Loveridge P, Smith S, Ibbotson S, George R, Hippisley-Cox J.   Oral presentation.  Advances in Disease Surveillance 2007; 2: 100.  [available online]

 

Quality of diabetes care in patients with severe mental illness: cross-sectional study.  Whyte S, Penny C, Phelan M, Hippisley-Cox J, Majeed A. Diabetic Medicine 2007; 22: 1442-1448. [available online]

   

Measuring performance and missing the point?  Heath I, Hippisley-Cox J Smeeth L.  British Medical Journal 2007; 335;1075-1076 doi:10.1136/bmj.39377.387373.AD [available online]

 

Risk of malignancy in patients with schizophrenia or bipolar disorder: nested case control study.  Hippisley-Cox J, Vinogradova Y, Coupland C, Parker C. Archives of General Psychiatry 2007; 64; 1368-1376 [available online].

 

Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study.  Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, May M, Brindle P. British Medical Journal 2007; 335:136-141 bmj.39261.471806.55 [available online]

  

Risk of colorectal cancer in patients taking statins and non-steroidal anti-inflammatory medication: nested case control study.  Vinogradova Y, Hippisley-Cox J, Coupland C, Logan R. Gastroenterology 2007; 133; 393-402. [available online] 

 

Inequalities in uptake of influenza vaccine by deprivation and risk group: time trends analysis.  Coupland C, Harcourt SE, Vinogradova Y, Smith GE, Joseph CA, Pringle M, Hippisley-Cox J. Vaccine 2007; 25 (42): 7363-7371 [available online]

 

Inequalities in uptake of influenza vaccine by deprivation and risk group: time trends analysis.  Coupland CAC, Harcourt S, Vinogradova Y, Smith G, Joseph C, Pringle M, Hippisley-Cox J. Journal of Epidemiology & Community Health 2007; 61 (Suppl 1): A40. [available online]

 

Rectal and postmenopausal bleeding: consultation and referral of patients with and without severe mental health problems.  Parker C, Hippisley-Cox J, Coupland C, Vinogradova Y.  British Journal of General Practice 2007; 57: 371-376 [available online]

 

Inequalities in the identification and treatment of hyperlipidaemia in coronary heart disease in patients with serious mental health problems: cross-sectional study.  Hippisley-Cox J, Parker C, Coupland C, Vinogradova Y. Heart 2007; 93: 1256-1262 doi:10.1136/hrt.2006.110171 [available online]

 

Developing a national primary care based early warning system for Health Protection – a surveillance tool for the future? Analysis of routinely collected data.  Smith GE, Hippisley-Cox J, Harcourt SE, Heaps M, Painter M, Porter, A, Pringle M. Journal of Public Health Medicine 2007; 29 (1) :75–82 [available online]

 

Primary Care Surveillance in the UK: Actions, Outcomes, Benefits.  Cooper DL, Smith GE, Elliot D, Harcourt S, Loveridge P, Smith S, Ibbotson S, George R. Hippisley-Cox J. Advances in Disease Surveillance 2007; 2: 100. [available online]

 

Quality of diabetes care in patients with severe mental illness: cross-sectional study.  Whyte S, Penny C, Phelan M, Hippisley-Cox J, Majeed A. Diabetic Medicine 2007: 24 (12): 1442 - 1448 [available online]

 

A description of the 4th verison of the QRESEARCH database. Report to the Department of Health, 2007. [available online].

An analysis of the top ten most commonly prescribed chemical entities in QRESEARCH. Report to the Department of Health, 2007. [available online]

A report on basic prescribing rates in older people using QRESEARCH. Report to the Department of Health, 2007.

Comorbidity of diseases in the new GMS contract for GPs: analysis of QRESEARCH data. Hippisley-Cox J, Pringle M. Report to the Department of Health, 2007. [available online]

Comparison of recording of procedures between QRESEARCH and Hospital Episode Statistics. Hippisley-Cox J, Ryan R, Pringle M. Report to the Department of Health, 2007. [available online]

Delivery and Organisation R&D (NCCSDO): NCCSDO. Mant J, Barton P, Ryan R, McManus R, Fletcher K, Kandiyali R, et al.

 

Determinants of consultation rates over time: Implications for estimating the national volume of consultations. Fenty J, Coupland C, Hippisley-Cox J, Gravelle H. QRESEARCH research highlights. Leeds: The Information Centre, 2007:79.

Diabetes in the UK: analysis of QRESEARCH data. Report to the Department of Health, 2007. [available online]

Distribution of risk factors and cardiovascular risk in QRESEARCH in 2007.  Report to the Department of Health.  Hippisley-Cox J. December 2007 [available online]

Evaluation of standards of care for osteoporosis and falls in primary care. Hippisley-Cox J, Bayly J, Potter J, Fenty J, Parker C. QRESEARCH research highlights. Leeds: The Information Centre, 2007:97. [available online]

Obesity in the UK: analysis of QRESEARCH data. Report to the Department of Health, 2007. [available online]

Patterns of prescribing of selective serotonin reuptake inhibitors in children in QRESEARCH. Report to the Department of Health, 2007. [available online]

Polypharmacy in the elderly: an analysis of QRESEARCH data. Report to the Department of Health, 2007. [available online]

Primary care epidemiology of allergic disorders: analysis using QRESEARCH database 2001-2006.   Hippisley-Cox J, Jumbu G, Fenty J, Holland R, A. P, Heaps M. QRESEARCH research highlights. Leeds: The Information Centre, 2007:84. [available online]

Repeat prescribing in the elderly: an analysis of QRESEARCH data. Report to the Department of Health, 2007. [available online]

Report to the National Audit Office: Quality of care for Stroke and TIA in General Practice using the new GMS contract indicators.  [available Online

Revising the General Medical Services Formula. Hippisley-Cox J, Coupland C, Pringle M, Marshall A, Ford J, Report to the Information Centre, 2007

QRESEARCH data. Report to the Department of Health, 2007. [available online]

Quality and Outcomes Time Series Analysis in QRESEARCH 2001 to 2006. Hippisley-Cox J, Vinogradova Y, Coupland C, Heaps M. QRESEARCH research highlights. Leeds: The Information Centre, 2007:39 [available online]

The population prevalence and inter-practice variation fo diabetes: analysis of QRESEARCH data. Report to the Department of Health, 2007.[available online]

Trends and variations in GMS indicators for coronary heart disease: analysis of QRESEARCH data. Report to the Department of Health, 2007.[available online] 

Trends and variations in GMS indicators for diabetes: analysis of QResearch data.  Report to the Department of Health, 2007

Trends and variations in GMS indicators for hypertension: analysis of QResearch data.  Report to the Department of Health 2007

Trends in Consultation Rates in General Practice 1995 to 2006: Analysis of the QRESEARCH database. Hippisley-Cox J, Fenty J, Heaps M. QRESEARCH research highlights. Leeds: The Information Centre, 2007:29. [available online]

Types of clinical and administrative user in QRESEARCH. Report to the Department of Health, 2007. [available online]

Validation of QFLU – comparison of key indicators with the RCGP weekly returns service 2003-2006. Hippisley-Cox J, Fenty J, Fleming D, Elliott A, Porter A.  Report to the Health Protection Agency, 2007

What is the Optimum Model of Service Delivery for Transient Ischaemic Diabetes in the UK: analysis of QRESEARCH data. Report to the Department of Health, 2007. [available online]

Risk of malignancy in patients with mental health problems (abstract).  Vinogradova Y, Hippisley-Cox J, Coupland C, Parker C. Family Practice 2006; 23: 1-142 Supplement

 

The effect of statins on mortality in patients with ischaemic heart disease: population-based cohort study with case control analysis.  Hippisley-Cox J, Coupland CAC. Heart 2006; 92; 752-758 [available online]

 

Sex inequalities in access to care for patients with diabetes in primary care: questionnaire survey.  Hippisley-Cox J, Yates J, Pringle M, Coupland CAC, Hammersley V. British Journal of General Practice 2006; 56; 342-348 [available online]

 

QFLU: new influenza monitoring in UK primary care to support pandemic influenza planning. Hippisley-Cox J, Smith S, Smith G, Porter A, Heaps M, Holland R, Fenty J, Harcourt S, George R, Charlett A, Pebody R, Painter M. Euro Surveillance 2006 Jun 22;11(6):E060622.4 [available online]

 

Determinants of consultation rates over time: implications for estimating the national volume of consultations.  Fenty J, Coupland C, Hippisley-Cox J, Gravelle H.  Report to the Health and Social Care Information Centre, 2006

 

Factors associated with variations in consultation rates. Fenty J, Coupland C, Hippisley-Cox J. Report to the NHS Information Centre, April 2006

 

Health outcomes for patients with serious mental health problems.   Hippisley-Cox J, Parker C, Vinogradova Y, Coupland C. Second report to the Disability Rights Commission, February 2006

 

Primary care epidemiology of allergic disorders: analysis using QRESEARCH database 2001-2006.  Hippisley-Cox J, Jumbu G, Fenty J, Holland R, Porter A, Heaps M.  Report to the Health and Social Care Information Centre, 2006 

 

Quality of care and health outcomes for patients with serious mental health problems. Hippisley-Cox J, Parker C, Vinogradova Y, Coupland C. Report to the Disability Rights Commission, 2006

 

Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. Hippisley-Cox J, Coupland CA.   British Medical Journal 2005; 330: 1366-1374 [available online]

 

Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case control analysis. Hippisley-Cox J, Coupland CAC.  British Medical Journal 2005; 330: 1059-1063 [available online]

 

Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. Hippisley-Cox J, Coupland CA, Logan RL. British Medical Journal 2005; 331: 1310-1316 [available online]

 

Coronary heart disease prevention and age inequalities: the first year of the National Service Framework for CHD.  Hippisley-Cox J, Pringle M, Coupland C, Cater R, Meal A. British Journal of General Practice 2005; 514: 369-375 [available online]

 

Assessing the accuracy of a computerised decision support system for digoxin dosing in primary care: an observational study. Kroese, WLG, Avery AJ, Savelyich BSP, Brown NS, Schers H, Howard R, Hippisley-Cox J, Horsfield P. Clinical Pharmacology & Therapeutics 2005; 30: 279-283 [available online]

 

Smoking cessation treatments within primary care. Prospective cohort study. Wilson A, Hippisley-Cox J, Coupland C, Coleman T, Britton J, Barratt S.  Tobacco Control 2005; 14: 242-246 [available online]

 

Comparison of key practice characteristics between general practices in England and Wales and general practices in the QRESEARCH database. Hippisley-Cox J, Vinogradova Y, Coupland, C, Pringle M. Report to the Information Centre, 2005 [available online]

Health Inequalities Experienced By People With Schizophrenia And Manic Depression: Analysis Of General Practice Data In England And Wales. Hippisley-Cox J, Pringle M.  Final report to the Disability Rights Commission April 2005 [available online]

 

Quality of care for stroke and TIA in general practice using the new GMS contract indicators. Hippisley-Cox J, Fenty J, Langford G, Pringle M, Coupland C. Report to the National Audit Office, November 2005

 

Results of the pairwise analysis for trends in consultation rates in UK general practices the calendar years 1995 to 2004. Hippisley-Cox J, Fenty J, Heaps M, Pringle M.  Report to the Information Centre, November 2005

 

Revising the GMS formula allocation formula.  Hippisley-Cox J, Coupland C, Pringle M, Marshall A, Ford J.  Report to the NHS Information Centre, December 2005

 

Trends in consultation rates in UK general practices the calendar years 1995 to 2004. Hippisley-Cox J, Fenty J, Heaps M, Pringle M. Report to the Information Centre, November 2005

QRESEARCH: a new general practice database for research.  Hippisley-Cox J, Stables D, Pringle M.  Journal of Informatics in Primary Care 2004; 12; 49-50.

 

Identifying patients with medication errors using the QRESEARCH database. Avery A, Hippisley-Cox J, Ryan R, Armstrong S, Morris C, Cantrill J. Pharmacoepidemiology and Drug Safety 2004; 13 (Supplement l): S61-62 [available online]

 

Association of deprivation, ethnicity and sex with quality indicators for diabetes: population based survey of 53,000 patients in primary care in. Hippisley-Cox J, O’Hanlon S, Coupland C.  British Medical Journal 2004; 329: 1267-1269 [available online]

 

Prevalence, care and outcomes for patients with diet controlled diabetes in primary care: cross sectional survey. Hippisley-Cox J, Pringle M.  Lancet 2004; 364: 423-442 [available online]

 

Primary and secondary prevention, and age inequalities: the effect of the first year of the implementation of the National Service Framework for Coronary Heart Disease in general practices in Trent: follow-up study. Hippisley-Cox J, Pringle M, Coupland C, Cater R, Meal A. British Journal of General Practice 2004; 12: 179-184

 

Achievement of new General Medical Services Indicators for Diabetes. Hippisley-Cox J, Pringle M. Report to the Department of Health, 2004

 

An analysis of prescribing of Methylphenidate Hydrochloride in QRESEARCH. Report to the Department of Health, 2004

 

An analysis of prescribing of SSRIs to Children. Hippisley-Cox J, Pringle M, Ryan R.  Report to the Statistics Division, Department of Health, 2004

 

An assessment of basic data quality in the pilot QRESEARCH database. Hippisley-Cox J, Pringle M, Ryan R.  Report to the Statistics Division, Department of Health, 2004

 

Basic prescribing rates in older people. Hippisley-Cox J, Pringle M, Ryan R.  Report to the Statistics Division, Department of Health, 2004

 

Comparison of the recording of procedures on QRESEARCH and HES. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department of Health, 2004

 

Comparing the top ten chemical entities in PACT and QRESEARCH.  Hippisley-Cox J, Pringle M, Ryan R.  Report to the Statistics Division, Department of Health, 2004

 

Defining user types in QRESEARCH. Hippisley-Cox J.  Report to the Statistics Division, Department of Health, 2004

Description of the National Database (4th download). Hippisley-Cox J. Report to the Department of Health, 2004

Diabetes in the UK, 1994 to 2003. Hippisley-Cox, J. Ryan R. Report to the Department of Health, 2004

 

Incidence, prevalence and care of patients with stroke in primary care in 2004. Hippisley-Cox J, Pringle M, Ryan R.  Report to the National Stroke Audit team, 2004

 

Incidence, prevalence and mortality of diabetes in the UK 1994 to 2003. Hippisley-Cox J, Ryan R. Report to the Statistics Division, Department of Health, 2004 

 

Inter-practice variation in the prevalence of diabetes. Hippisley-Cox J. Report to the Department of Health, 2004

First National Stroke Audit in Primary Care - Final Report to the National Audit Office, 2004 [available Online]

Morbidity and mortality on the QRESEARCH database. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department of Health, 2004 

 

Polypharmacy in the elderly. Hippisley-Cox J, Pringle M, Ryan R.  Report to the Statistics Division, Department of Health, 2004 

 

Prescribing in older people by BNF Chapter. Hippisley-Cox J, Pringle M.  Report to the Statistics Division, Department of Health, 2004

 

Prescribing of Methylphenidate Hydrochloride in children. Hippisley-Cox J, Pringle M, Ryan R. Report to the Statistics Division, Department of Health, 2004 

 

Prevalence of conditions in the new General Medical Services. Hippisley-Cox J, Pringle M.  Report to the Department of Health, 2004

 

Stroke: prevalence, incidence & care in general practice 2002-2004. Hippisley-Cox J, Pringle M, Ryan R.  Final Report to the National Stroke Audit Team, Royal College of Physicians, September 2004

 

The effect of age, sex, deprivation and other factors on electrolytes in patients on ACE inhibitors or loop diuretics in primary care: a case control study. Nwabuoku. MPH Thesis. University of Nottingham 2004

Trends in obesity in the UK 1994 to 2003.  Hippisley-Cox J. Ryan R. Report to the Department of Health, 2004 

 

Understanding QRESEARCH data structures. Hippisley-Cox J. Report to the Statistics Division, Department of Health, 2004

Papers Pre-QRESEARCH - illustrating the potential

The following papers were based on general practice clinical data before QRESEARCH was created and illustrate the potential for QRESEARCH:

General Practitioners attitudes towards provision of services to young people aged under 16: a cross sectional survey. Bethea J, Hippisley-Cox J, Coupland CA, Pringle M. Quality in Primary Care; 2007; 15: 11-19.

General practice characteristics associated with rates of testing and detection of hepatitis C: cross-sectional study in Nottingham and Derbyshire. Coupland C, Hippisley-Cox J, Smith S, Irving W, Pringle M, Ryder S, Neal K, Cater R, Thompson B, Pugh S, Bicknell M, Bullock D. British Journal of General Practice 2006; 56: 620-623. [available online]

Primary and secondary prevention and age inequalities - the effect of the first year of the National Service Framework for Coronary Heart Disease. Hippisley-Cox J, Pringle M, Cater R, Coupland C, Meal A. British Journal of General Practice 2004; 12: 179-184

Methodology for Assessing the Usefulness of General Practice Data for Research in One Research Network. Hippisley-Cox J, Hammersley V, Pringle M, Coupland C, Crown N, Wright L. Health Informatics Journal 2004; 10 : 91-109.

The electronic record in primary care – regression or progression?   A cross-sectional survey. Hippisley-Cox J, Pringle M, Cater R, Wynn A, Hammersley V, Coupland C, Hapgood R, Horsfield P, Teasdale SJ. British Medical Journal 2003; 326: 1439-1443. [available online]

A cross sectional survey of the effectiveness of lipid lowering drugs in lowering serum cholesterol in 17 general practices: how well do they work? Hippisley-Cox J, Cater R, Pringle M, Coupland C. British Medical Journal, 2003; 326: 689-694 [available online]  

A case-control study on the effect of hormone replacement therapy on ischaemic heart disease. Hippisley-Cox J, Pringle M, Crown N, Coupland C. British Journal of General Practice 2003; 53 : 191-196 [available online]

Married couples' risk of the same disease: cross sectional study. Hippisley-Cox J, Coupland C, Pringle M, Crown N, Hammersley V. British Medical Journal, 2002; 325: 636-638 [available online]

A comparison of research general practices and their patients with other practices - a cross-sectional study in Trent. Hammersley V, Hippisley-Cox J, Wilson A, Pringle M. British Journal of General Practice , 2002; 52 : 463-468 [available online]

Antidepressants as risk factor for ischaemic heart disease: case controlled study in primary care. Hippisley-Cox J, Pringle M, Hammersley V, Crown N, Wynn A, Coupland C. British Medical Journal, 2001; 323: 666-669 [available online]

Sex inequalities in ischaemic heart disease in general practice: cross sectional survey. Hippisley-Cox J, Pringle M, Crown N, Meal A, Wynn A. British Medical Journal, 2001; 322: 832-834 [available online]

General practice workload implications for the national service framework for coronary heart disease: cross sectional survey. Hippisley-Cox J, Pringle M. British Medical Journal, 2001; 323: 269-270 [available online]

Inequalities in access to coronary angiography and revascularisation: the association of deprivation and location of primary care services.  Hippisley-Cox J, Pringle M. British Journal of General Practice, 2000; 50: 449-454 [available online]

Time changes in new cases of ischaemic heart disease. Meal A, Pringle M, Hammersley V. Family Practice, 2000; 17: 394-400 [available online]

Depression as a risk factor for ischaemic heart disease in men: population cased case-control study. Hippisley-Cox J, Fielding K, Pringle M. British Medical Journal, 1998; 316: 1714-1749 [available online]

Are spouses of patients with hypertension at increased risk of having hypertension? A population-based case-control study. Hippisley-Cox J, Pringle M. British Journal of General Practice, 1998; 4: 1580-1584

 
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